Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Yufu, Japan.
Am J Dermatopathol. 2020 Aug;42(8):604-607. doi: 10.1097/DAD.0000000000001613.
Dendritic cell neurofibroma with pseudorosettes (DCNP) is a rare benign peripheral nerve sheath tumor. Till date, 34 cases of DCNP arising from various sites have been reported. Histopathologically, DCNP is known to present with characteristic pseudorosettes, in which a type II cell is surrounded by type I cells. In the present report, we discuss the rare case of a 63-year-old man diagnosed with DCNP on the left flank (size: approximately 10 mm). On microscopic examination of the resected lesion, we observed the characteristic pseudorosettes with centrally placed type I cells, which exhibited small, dark, slightly irregular oval nuclei with nuclear inclusions, surrounded by type II cells, which showed a large pale nucleus with a constriction, a small nucleolus, and mildly eosinophilic cytoplasm. The type II cells were positive for S-100, CD57, LAMP2, fascin, and factor XIIIa. Although previous reports have suggested that type II cells exhibit a dendritic form, our immunohistochemical analyses revealed that these cells were dermal interstitial dendritic cells.
树突状细胞神经纤维瘤伴假菊形团结构（DCNP）是一种罕见的良性周围神经鞘肿瘤。迄今为止，已有 34 例发生于不同部位的 DCNP 被报道。组织病理学上，DCNP 以其特征性的假菊形团结构为特征，其中 II 型细胞被 I 型细胞环绕。在本报告中，我们讨论了一例罕见的 63 岁男性左腰部 DCNP 病例（大小：约 10mm）。在对切除病变的显微镜检查中，我们观察到具有中央 I 型细胞的特征性假菊形团结构，这些细胞具有小而暗的、略微不规则的椭圆形核，核内有包涵体，被 II 型细胞包围，II 型细胞显示大而淡的核，有缢痕，小核仁，和轻度嗜酸性细胞质。II 型细胞对 S-100、CD57、LAMP2、 Fascin 和因子 XIIIa 呈阳性。尽管之前的报道表明 II 型细胞呈树突状，但我们的免疫组织化学分析显示这些细胞是真皮间质树突状细胞。
