Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Arch Virol. 2012 Jan;157(1):121-7. doi: 10.1007/s00705-011-1115-8. Epub 2011 Sep 25.
Arenaviruses and filoviruses are capable of causing hemorrhagic fever syndrome in humans. Limited therapeutic and/or prophylactic options are available for humans suffering from viral hemorrhagic fever. In this report, we demonstrate that pre-treatment of host cells with the kinase inhibitors genistein and tyrphostin AG1478 leads to inhibition of infection or transduction in cells infected with Ebola virus, Marburg virus, and Lassa virus. In all, the results demonstrate that a kinase inhibitor cocktail consisting of genistein and tyrphostin AG1478 is a broad-spectrum antiviral that may be used as a therapeutic or prophylactic against arenavirus and filovirus hemorrhagic fever.
沙粒病毒和丝状病毒能够引起人类出血热综合征。对于患有病毒性出血热的人类，可用的治疗和/或预防方法有限。在本报告中，我们证明用激酶抑制剂染料木黄酮和 tyrphostin AG1478 预处理宿主细胞可导致感染埃博拉病毒、马尔堡病毒和拉萨病毒的细胞的感染或转导受到抑制。总之，结果表明，由染料木黄酮和 tyrphostin AG1478 组成的激酶抑制剂混合物是一种广谱抗病毒药物，可作为抗沙粒病毒和丝状病毒出血热的治疗或预防药物。
