Zakaryan Hovakim, Arabyan Erik, Oo Adrian, Zandi Keivan
Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS RA, Hasratyan 7, 0014, Yerevan, Armenia.
Department of Medical Microbiology, Faculty of Medicine, Tropical Infectious Disease Research and Education Center (TIDREC), University of Malaya, Kuala Lumpur, Malaysia.
Arch Virol. 2017 Sep;162(9):2539-2551. doi: 10.1007/s00705-017-3417-y. Epub 2017 May 25.
Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids have been investigated for their potential antiviral activities and several of them exhibited significant antiviral properties in in vitro and even in vivo studies. This review summarizes the evidence for antiviral activity of different flavonoids, highlighting, where investigated, the cellular and molecular mechanisms of action on viruses. We also present future perspectives on therapeutic applications of flavonoids against viral infections.
黄酮类化合物作为植物产生的次生代谢产物广泛分布，在植物生理学中发挥重要作用，具有多种潜在的生物学益处，如抗氧化、抗炎、抗癌、抗菌、抗真菌和抗病毒活性。不同的黄酮类化合物已被研究其潜在的抗病毒活性，其中一些在体外甚至体内研究中表现出显著的抗病毒特性。本综述总结了不同黄酮类化合物抗病毒活性的证据，重点介绍了在研究中发现的对病毒的细胞和分子作用机制。我们还提出了黄酮类化合物在治疗病毒感染方面的未来应用前景。
