Azevedo Rebeca Souza, Pires Fábio Ramôa, Gouvêa Adriele Ferreira, Lopes Márcio Ajudarte, Jorge Jacks
Oral Pathology, School of Dentistry, Fluminense Federal University, Rua Doutor Silvio Henrique Braune, 22-Centro, CEP: 28625-650, Nova Friburgo, Rio de Janiero, Brazil.
Oral Maxillofac Surg. 2012 Jun;16(2):227-32. doi: 10.1007/s10006-011-0294-5. Epub 2011 Sep 27.
Leiomyosarcoma is rare in the oral cavity, where it may arise as primary, radiation-associated, or metastatic tumor. This article reports two cases of oral leiomyosarcoma, discussing the range of clinicopathological features and the significance of these presentations.
One case is a radiation-associated leiomyosarcoma arising in the tongue of a 71-year-old male occurring 22 years after radiation therapy for tonsil squamous cell carcinoma that was surgically treated. The other one is a mandible metastasis from a retroperitoneal widespread leiomyosarcoma in a 69-year-old man, who was treated by surgery and chemotherapy but died from the disease.
Post-radiotherapy sarcomas of the oral cavity and oral metastasis from soft tissue sarcomas are very uncommon, but based on patient's clinical history, they should be considered by oral health care providers in order to allow an early diagnosis and proper and timely management. Finally, to the best of our knowledge, this seems to be the first reported case of tongue leiomyosarcoma arising in a previously irradiated field.
平滑肌肉瘤在口腔中较为罕见，可原发、与放疗相关或为转移性肿瘤。本文报告两例口腔平滑肌肉瘤病例，探讨其临床病理特征范围及这些表现的意义。
一例为与放疗相关的平滑肌肉瘤，发生于一名71岁男性的舌部，该患者在扁桃体鳞状细胞癌放疗22年后发病，接受了手术治疗。另一例为一名69岁男性，下颌骨转移自腹膜后广泛的平滑肌肉瘤，接受了手术和化疗，但最终死于该疾病。
口腔放疗后肉瘤及软组织肉瘤的口腔转移非常罕见，但基于患者的临床病史，口腔医疗保健人员应予以考虑，以便早期诊断并进行恰当及时的处理。最后，据我们所知，这似乎是首例报道的在先前放疗区域发生的舌平滑肌肉瘤病例。
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