Nikitakis Nikolaos G, Lopes Marcio A, Bailey Jonathan S, Blanchaert Remy H, Ord Robert A, Sauk John J
Department of Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore 666 W. Baltimore Street, Room 4-C-02, Baltimore, MD 21201-1586, USA.
Oral Oncol. 2002 Feb;38(2):201-8. doi: 10.1016/s1368-8375(01)00047-1.
Leiomyosarcoma of the oral cavity is a very rare tumor that is associated with aggressive clinical behavior and low survival. In this paper, we report two new cases of leiomyosarcoma affecting the mandibular gingiva and mandible of a 35-year-old male and the mandible of a 51-year-old female. Given the difficulty in the histopathologic discrimination between benign and malignant smooth muscle tumors and the absence of reliable histologic parameters for prognostication of leiomyosarcomas, we evaluated the diagnostic and prognostic value of various immunohistochemical and molecular markers. By means of immunohistochemistry and quantitative real-time PCR analysis, we detected protein expression of PCNA, bcl-2, CDK4, p53 and MDM2 in both our cases and MDM2 amplification in our second case. The literature, pertinent to oral leiomyosarcoma and to molecular analysis of smooth muscle tumors, is reviewed.
口腔平滑肌肉瘤是一种非常罕见的肿瘤，具有侵袭性的临床行为且生存率低。在本文中，我们报告了两例新的平滑肌肉瘤病例，一例发生于一名35岁男性的下颌牙龈和下颌骨，另一例发生于一名51岁女性的下颌骨。鉴于在组织病理学上难以区分良性和恶性平滑肌肿瘤，且缺乏可靠的组织学参数来预测平滑肌肉瘤的预后，我们评估了各种免疫组化和分子标志物的诊断及预后价值。通过免疫组化和定量实时PCR分析，我们在两例病例中均检测到PCNA、bcl-2、CDK4、p53和MDM2的蛋白表达，在第二例病例中检测到MDM2扩增。本文还对与口腔平滑肌肉瘤及平滑肌肿瘤分子分析相关的文献进行了综述。
