Jacobs Volker R, Zemzoum Iris, Kremer Marcus, Gottschalk Nina, Baumgärtner Anne K, Krol Janna, Kiechle Marion
Department of Obstetrics and Gynecology, Technical University Munich, Germany.
Onkologie. 2010;33(1-2):49-52. doi: 10.1159/000264625. Epub 2010 Jan 22.
Leiomyosarcoma of the fallopian tube is an extremely unusual gynecologic neoplasm. Since 1886, only 19 of about 35 sarcomas of the fallopian tube have been identified as leiomyosarcomas. As such, clinical diagnosis and therapy management are difficult.
We report on the case of a 59-year-old woman with leiomyosarcoma of the fallopian tube and liver metastases at the time of diagnosis. After initial tumor debulking, she received palliative chemotherapy with gemcitabine 900 mg/m(2) (d1+8) and docetaxel 100 mg/m(2) (d8) (q21). For additional bone metastases, she started local radiation plus bisphosphonates (q28). After 2 cycles of chemotherapy, the disease progressed, and the patient died within 8 months of diagnosis. A review of the literature is given.
Primary metastatic leiomyosarcoma of the fallopian tube is a progressive disease with limited therapy options. For better prognostic evaluation and disease management in such rare cases, it is important to report and compare more cases regarding course of disease and outcome.
输卵管平滑肌肉瘤是一种极为罕见的妇科肿瘤。自1886年以来，在约35例输卵管肉瘤中，仅有19例被确诊为平滑肌肉瘤。因此，临床诊断和治疗管理颇具难度。
我们报告一例59岁女性患者，诊断时患有输卵管平滑肌肉瘤并伴有肝转移。在初次肿瘤减瘤手术后，她接受了姑息化疗，使用吉西他滨900mg/m²（第1天和第8天）和多西他赛100mg/m²（第8天）（每21天重复）。针对额外的骨转移，她开始接受局部放疗并联合双膦酸盐治疗（每28天重复）。化疗2个周期后，疾病进展，患者在诊断后8个月内死亡。并对相关文献进行了综述。
原发性输卵管转移性平滑肌肉瘤是一种进展性疾病，治疗选择有限。对于此类罕见病例，为了更好地进行预后评估和疾病管理，报告并比较更多关于疾病进程和结局的病例非常重要。
