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减重手术后患者的低热量家庭肠外营养和营养参数。

Hypocaloric home parenteral nutrition and nutrition parameters in patients following bariatric surgery.

机构信息

Center for Human Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

出版信息

Nutr Clin Pract. 2011 Oct;26(5):577-82. doi: 10.1177/0884533611416125.

Abstract

BACKGROUND

Surgical intervention is considered an acceptable treatment for morbid obesity. Complications following bariatric surgery procedures (BSPs) may necessitate home parenteral nutrition (HPN). No studies have been published on patients receiving HPN following BSP complications. The study aim was to determine if hypocaloric HPN has an effect on body mass index (BMI), albumin, and HPN complications.

METHODS

A historic cohort of patients was identified from a clinical database. Obese patients (BMI ≥35 kg/m(2)) who underwent BSP and received HPN for an anastomotic leak/fistula or bowel obstruction were included. Comparisons for start and end of therapy were made for calorie and protein intake, BMI, white blood cell count, and serum albumin level. Readmissions and metabolic and infectious complications were recorded. Obese patients received hypocaloric feeds to promote weight loss and protein for wound healing.

RESULTS

Twenty-three patients were included for an average study length of 1.5 months. Patients received an average of 1.2 g of protein and a median of 13.6 kcal per kg actual body weight (ABW) per day. BMI decreased by 7.1% ± 5.2%, from a median of 39.8 to 37.1, and serum albumin increased by 12.5%, from 2.8 ± 0.5 to 3.2 ± 0.6 g/dL. Readmissions occurred in 52.2% of patients with 40.0% of complications related to HPN.

CONCLUSIONS

Hypocaloric HPN is efficacious in maintaining adequate nutrition while allowing for weight loss in morbidly obese patients following complications of bariatric surgery. Frequency of HPN complications was comparable to those reported in the literature.

摘要

背景

手术干预被认为是治疗病态肥胖的一种可接受的治疗方法。减重手术(BSP)后出现并发症可能需要家庭肠外营养(HPN)。目前尚无关于 BSP 并发症后接受 HPN 治疗的患者的研究报告。本研究旨在确定低热量 HPN 是否对体重指数(BMI)、白蛋白和 HPN 并发症有影响。

方法

从临床数据库中确定了一组历史队列患者。将接受 BSP 并因吻合口漏/瘘或肠梗阻而接受 HPN 的肥胖患者(BMI≥35kg/m²)纳入研究。对治疗开始和结束时的热量和蛋白质摄入、BMI、白细胞计数和血清白蛋白水平进行了比较。记录再入院情况和代谢及感染并发症。给予肥胖患者低热量喂养以促进体重减轻和伤口愈合所需的蛋白质。

结果

共有 23 例患者入组,平均研究时间为 1.5 个月。患者平均接受 1.2g 蛋白质,实际体重(ABW)中位数为 13.6kcal/kg/d。BMI 下降了 7.1%±5.2%,从中位数 39.8 降至 37.1,血清白蛋白增加了 12.5%,从 2.8±0.5g/dL 增加至 3.2±0.6g/dL。52.2%的患者再次入院,40.0%的并发症与 HPN 相关。

结论

低热量 HPN 在维持营养充足的同时,允许病态肥胖患者在减重手术后的并发症后减轻体重,在维持营养充足的同时,允许病态肥胖患者在减重手术后的并发症后减轻体重。HPN 并发症的发生率与文献报道的相似。

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