渗出性年龄相关性黄斑变性易感性与谷胱甘肽S-转移酶Z1（GSTZ1）的三种基因多态性
Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1).
作者信息
Othman Hasan, Saadat Iraj, Farvardin-Jahromi Majid, Saadat Mostafa
机构信息
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
出版信息
Eur J Ophthalmol. 2012 May-Jun;22(3):431-5. doi: 10.5301/ejo.5000053.
PURPOSE
To investigate whether genetic polymorphisms of GSTZ1 contribute to the development of exudative age-related macular degeneration (AMD).
METHODS
The present case-control study consisted of 112 patients (44 female, 68 male) with exudative AMD and 112 sex frequency-matched healthy controls were randomly selected from unrelated volunteers in the same clinic. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism-based method.
RESULTS
There was no significant association between study polymorphisms and susceptibility to exudative AMD. Considering the significant difference in age distribution between cases and controls, age was used as a covariate in further analysis. After odds ratio adjustment for age, the same results were observed. The study polymorphisms showed linkage disequilibrium. Analysis revealed that there was no difference between cases and controls for the prevalence of the haplotypes of GSTZ1.
CONCLUSIONS
Our study did not support any association between susceptibility to exudative AMD and polymorphisms of GSTZ1.
目的
研究谷胱甘肽硫转移酶Z1（GSTZ1）基因多态性是否与渗出性年龄相关性黄斑变性（AMD）的发生有关。
方法
本病例对照研究包括112例渗出性AMD患者（44例女性，68例男性），并从同一诊所的无关志愿者中随机选取112名性别频率匹配的健康对照。采用基于聚合酶链反应-限制性片段长度多态性的方法确定基因型。
结果
所研究的多态性与渗出性AMD易感性之间无显著关联。考虑到病例组和对照组年龄分布存在显著差异，在进一步分析中将年龄作为协变量。对年龄进行优势比调整后，观察到相同结果。所研究的多态性显示出连锁不平衡。分析表明，GSTZ1单倍型在病例组和对照组中的流行率无差异。
结论
我们的研究不支持渗出性AMD易感性与GSTZ1多态性之间存在任何关联。
Zotero 插件