Karakaş-Celik Sevim, Aras Nurcan, Ateş Cengiz
Lab Med. 2014 Winter;45(1):37-42. doi: 10.1309/lmbprab33kk5ejba.
To determine whether there is a relationship between genetic polymorphisms of glutathione S-transferase zeta 1 (GSTZ1) and gastric cancer. The contribution of GSTZ1 genotypes to susceptibility to the risk of gastric cancer (GC) is still unclear.
Using a polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) method in an ethnic Turkish population, we examined the frequency of the GSTZ1 gene polymorphism in patients with GC patients (n = 73) and control individuals (n = 80).
For GSTZ1 A94G polymorphism, in the group of patients with the GC, the frequency of the GG genotype was quite a bit higher in comparison with that of the control group; however, this increase was not statistically significant. For the GSTZ1 A124G polymorphism, the GSTZ1 heterozygous genotype (AG) occurred more frequently in GC patients than in controls; however, it was not associated with risk of developing GC. We found no significant association between the A94G or A124G variants of the GSTZ1 gene and risk of gastric cancer.
Our data indicate no association between GSTZ1 genotypes and risk of gastric cancer. Despite its marked decline in many industrialized countries, gastric cancer remains the most common cause of death by cancer in areas such as Japan, Turkey, and South America. Gastric cancer (GC) is a disease of complex etiology that involves intimately interconnected infectious, dietary, environmental, and genetic factors. Although it has been estimated that 67% of GCs could be prevented by implementing lifestyle changes, the fact that some individuals develop GC but others do not, despite exposure to similar potentially carcinogenic factors, suggests that genetic predisposition may also play an important role in the etiology of GC.
确定谷胱甘肽S-转移酶ζ1（GSTZ1）基因多态性与胃癌之间是否存在关联。GSTZ1基因型对胃癌（GC）易感性的影响仍不清楚。
在土耳其人群中，我们采用基于聚合酶链反应（PCR）的限制性片段长度多态性（RFLP）方法，检测了73例GC患者和80例对照个体中GSTZ1基因多态性的频率。
对于GSTZ1 A94G多态性，GC患者组中GG基因型的频率比对照组略高；然而，这种增加无统计学意义。对于GSTZ1 A124G多态性，GC患者中GSTZ1杂合基因型（AG）的出现频率高于对照组；然而，它与发生GC的风险无关。我们发现GSTZ1基因的A94G或A124G变体与胃癌风险之间无显著关联。
我们的数据表明GSTZ1基因型与胃癌风险之间无关联。尽管在许多工业化国家胃癌发病率显著下降，但在日本、土耳其和南美洲等地区，胃癌仍是癌症死亡的最常见原因。胃癌（GC）是一种病因复杂的疾病，涉及密切相关的感染、饮食、环境和遗传因素。尽管据估计通过改变生活方式可预防67%的GC，但一些人尽管暴露于相似的潜在致癌因素却患GC，而另一些人则未患病，这一事实表明遗传易感性在GC病因中可能也起重要作用。
