Dipartimento di Medicina Sperimentale, Centro di Eccellenza per le Richerche Biomediche, Università degli Studi di Genova, 16132 Genova, Italy.
Adv Exp Med Biol. 2012;946:295-308. doi: 10.1007/978-1-4614-0106-3_17.
In recent years, it has been emphasized the role of the crosstalk between natural killer (NK) cells and monocyte-derived dendritic cells dendritic cells (moDCs) in the regulation of the early phases of innate immunity innate immunity and of the subsequent adaptive immune responses. NK cells and DCs coordinate their response communicating through direct cell-to-cell contact and soluble factors. NK cells appear to contribute to the quality control of immature DCs (iDCs) undergoing maturation. On the other hand, DCs may shape the magnitude of innate immune responses by modulating the NK-mediated cytolytic activity against tumors or infected cells. Recent studies suggest that the cooperation between NK cells and DCs is also critical in several anti-viral responses. In particular, NK cells are capable of effectively counteracting viral immune evasion immune evasion strategies by eliminating infected DCs, that display impaired antigen presenting functions, thus indirectly favoring the development of adaptive immune responses to viral antigens cross-presented by healthy DCs.
近年来，人们强调了自然杀伤 (NK) 细胞与单核细胞衍生的树突状细胞 (moDC) 之间的串扰在调节先天免疫的早期阶段和随后的适应性免疫反应中的作用。NK 细胞和 DC 通过直接细胞间接触和可溶性因子来协调它们的反应。NK 细胞似乎有助于正在成熟的未成熟 DC(iDC)的质量控制。另一方面，DC 可以通过调节 NK 介导的对肿瘤或感染细胞的细胞溶解活性来塑造先天免疫反应的程度。最近的研究表明，NK 细胞和 DC 之间的合作对于几种抗病毒反应也至关重要。特别是，NK 细胞能够通过消除显示抗原呈递功能受损的感染 DC，有效地对抗病毒的免疫逃避策略，从而间接有利于由健康 DC 交叉呈递的病毒抗原的适应性免疫反应的发展。
