Piura B, Glezerman M, Galper Y, Segal S, Cohen Y
Division of Obstetrics & Gynecology, Soroka Medical Center, Ben-Gurion University of the Negev, Israel.
Eur J Obstet Gynecol Reprod Biol. 1990 Jul-Aug;36(1-2):203-8. doi: 10.1016/0028-2243(90)90068-c.
The cases of two patients with epithelial ovarian carcinoma who had been treated with surgery and cisplatin-containing combination chemotherapy and had developed brain metastases are described. Modern protocols for management of advanced-stage epithelial ovarian carcinoma have resulted in prolonging the lives of the patients sufficiently for central nervous system metastases to become apparent and possible resistence of the 'blood brain' barrier to the currently used chemotherapeutic agents may have left the CNS 'unprotected' from metastases.
本文描述了两名上皮性卵巢癌患者的病例，这两名患者接受了手术及含顺铂的联合化疗，随后出现了脑转移。晚期上皮性卵巢癌的现代治疗方案已使患者的生命得到了足够延长，从而使中枢神经系统转移变得明显，并且目前所用化疗药物可能对“血脑”屏障存在耐药性，这可能导致中枢神经系统对转移缺乏“保护”。
