Sulkes A, Siegal T, Gez E
Gynecol Oncol. 1985 Feb;20(2):204-8. doi: 10.1016/0090-8258(85)90143-x.
A patient with an advanced adenocarcinoma of the ovary developed spontaneous central nervous system (CNS) bleeding as initial evidence of brain involvement by a tumor. The rarity of this phenomenon in patients with ovarian tumors is emphasized and the incidence and course of brain metastases in ovarian cancer are reviewed. Similar to previous reports, our patient had extra abdominal systemic disease at the time CNS involvement was diagnosed. Although good short-term results were achieved with whole-brain irradiation, the prognosis for these patients remains dismal. The incidence of brain metastases may increase in patients with advanced ovarian malignancies given the possibility of achieving long-term survival in a significant percentage of women with widespread disease being currently treated with intensive systemic chemotherapy.
一名晚期卵巢腺癌患者出现自发性中枢神经系统（CNS）出血，作为肿瘤脑转移的初始证据。强调了这种现象在卵巢肿瘤患者中的罕见性，并回顾了卵巢癌脑转移的发生率和病程。与之前的报道相似，我们的患者在诊断出中枢神经系统受累时已有腹外系统性疾病。尽管全脑放疗取得了良好的短期效果，但这些患者的预后仍然很差。鉴于目前接受强化全身化疗的大部分广泛疾病女性有可能实现长期生存，晚期卵巢恶性肿瘤患者脑转移的发生率可能会增加。
