Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey.
Angiology. 2012 Jul;63(5):386-9. doi: 10.1177/0003319711419837. Epub 2011 Sep 22.
The main purpose of this study was to investigate the relation between carotid intima-media thickness (CIMT) and coronary artery disease (CAD) complexity. Consecutive patients (n = 360) with CAD confirmed by coronary angiography were enrolled. Mean CIMT and the overall SYNTAX score (SXscore) were 0.87 ± 0.12 mm and 15 ± 9, respectively. In univariate analysis, there was a significant correlation between the overall SXscore and CIMT (r = .42, P < .001), age (r = .23, P < .001), hypertension (r = .27, P = 0.001), diabetes (r = 0.11, P = 0.02), smoking (r = .24, P = .01), dyslipidemia (r = .2, P = 0.03), and β-blocker use (r = .19, P < .001). In multivariate analysis, CIMT (β = .34, P < .001) and age (β = .11, P < .019) were independently associated with SXscore. We have demonstrated a significant relation between CIMT and SXscore. Although this study is correlative and no causative conclusions can be drawn, our findings suggest that increased CIMT could reflect complex coronary artery lesions.
本研究的主要目的是探讨颈动脉内膜中层厚度（CIMT）与冠状动脉疾病（CAD）复杂性之间的关系。连续入选经冠状动脉造影证实为 CAD 的患者（n = 360）。平均 CIMT 和整体 SYNTAX 评分（SXscore）分别为 0.87 ± 0.12mm 和 15 ± 9。在单因素分析中，整体 SXscore 与 CIMT 之间存在显著相关性（r =.42，P <.001），与年龄（r =.23，P <.001）、高血压（r =.27，P = 0.001）、糖尿病（r = 0.11，P = 0.02）、吸烟（r =.24，P =.01）、血脂异常（r =.2，P = 0.03）和β受体阻滞剂的使用（r =.19，P <.001）。在多因素分析中，CIMT（β =.34，P <.001）和年龄（β =.11，P <.019）与 SXscore 独立相关。我们已经证明了 CIMT 与 SXscore 之间存在显著关系。尽管本研究是相关性的，不能得出因果关系的结论，但我们的发现表明，CIMT 的增加可能反映了复杂的冠状动脉病变。
