Department of Child Health, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Clin Appl Thromb Hemost. 2012 Mar-Apr;18(2):189-94. doi: 10.1177/1076029611418962. Epub 2011 Sep 23.
Development of cardiovascular diseases could originate in early childhood. However, reference values of hemostatic parameters and adipokines in preschool children remain to be explored. We measured blood levels of adipokines and parameters of the hemostatic/fibrinolytic systems in 167 healthy children aged 4 to 6 years at 9:00 to 10:30 am after a strictly enforced overnight fast. Participants with body mass index (BMI) values ≥90th percentile had significantly higher values of systolic blood pressure and heart rate, as well as blood levels of insulin, coagulation factor (F) VII, FX, protein S, leptin, and homeostasis model assessment of insulin resistance (HOMA-IR), and lower values of desacyl-ghrelin than children with BMI < 90th percentile. Circulating levels of fibrinogen and leptin increased with increased number of cardiovascular risk factors. Stepwise regression analysis identified many hematological variables to be associated with features of the metabolic syndrome. The results implicated the hemostatic/fibrinolytic system or adipokines in the insidious progression of cardiovascular diseases from an early age.
心血管疾病的发生可能起源于儿童早期。然而，学龄前儿童的止血参数和脂肪因子的参考值仍有待探索。我们在上午 9:00 至 10:30 之间，对 167 名年龄在 4 至 6 岁之间、严格禁食一夜后的健康儿童测量了脂肪因子和止血/纤维蛋白溶解系统参数的血液水平。体重指数（BMI）值≥第 90 百分位数的参与者的收缩压和心率、胰岛素、凝血因子（F）VII、FX、蛋白 S、瘦素和胰岛素抵抗的稳态模型评估（HOMA-IR）水平显著较高，而去酰化-ghrelin 值则较低。纤维蛋白原和瘦素的循环水平随着心血管危险因素数量的增加而增加。逐步回归分析确定了许多血液学变量与代谢综合征的特征有关。结果表明，止血/纤维蛋白溶解系统或脂肪因子参与了心血管疾病从早期开始的隐匿进展。
