Department of Pharmacology, Second Military Medical University, Shanghai, China.
CNS Neurosci Ther. 2011 Oct;17(5):577-84. doi: 10.1111/j.1755-5949.2011.00264.x.
Stroke is a major cause of disability and death worldwide. Prevention aimed at risk factors of stroke is the most effective strategy to curb the stroke pandemic. Hypertension is one of the most important risk factors for stroke. Despite the substantial evidence of the benefits of lowering blood pressure, conventional treatment does not normalize the burden of major cardiovascular events in patients with hypertension. Fully understanding the factors involved in the hypertension-induced stroke helps to develop new strategies for stroke prevention. Antihypertensive therapies selected should have positive blood pressure-independent effects on stroke risk. This review summarizes the factors involved in the hypertension-induced stroke, such as oxidative stress, inflammation, and arterial baroreflex dysfunction, and potential strategies for its prevention, therefore, provides clues for clinicians.
中风是全球范围内导致残疾和死亡的主要原因。针对中风危险因素进行预防是遏制中风流行的最有效策略。高血压是中风最重要的危险因素之一。尽管有大量证据表明降低血压有益，但常规治疗并不能使高血压患者的主要心血管事件负担正常化。充分了解高血压引起中风的相关因素有助于制定新的中风预防策略。选择的降压治疗应该具有独立于血压的积极作用，降低中风风险。本综述总结了高血压引起中风的相关因素，如氧化应激、炎症和动脉压力感受反射功能障碍，以及潜在的预防策略，为临床医生提供了线索。
