Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA.
J Clin Psychiatry. 2011 Sep;72(9):e28. doi: 10.4088/JCP.9101tx2c.
Nonadherence to antipsychotic medications is an enormous challenge for clinicians and patients in the treatment of schizophrenia. Nonadherence and partial adherence are associated with high rates of relapse, rehospitalization, and suicide attempts. Assessing adherence can be difficult because patients are likely to overestimate their medication adherence and may not report skipping doses or discontinuing medication. Strategies for assessing and improving adherence rates among patients with schizophrenia, including the use of long-acting depot antipsychotic medications, are discussed.
抗精神病药物治疗不依从是精神分裂症临床治疗中的巨大挑战，无论是完全不依从还是部分依从均与高复发率、再住院率和自杀企图相关。评估依从性可能较为困难，因为患者很可能会高估其药物依从性，并且可能不会报告漏服或停药。本文讨论了评估和提高精神分裂症患者药物依从率的策略，包括使用长效注射用抗精神病药物。
