Moussa N M, Ghannoum M A, Whittaker P A, el-Ezaby M S, Quraman S
Department of Biochemistry, University of Kuwait.
Microbios. 1990;62(252-253):165-78.
The effects of cisplatin and two novel palladium complexes of possible cancer chemotherapeutic value on the yeasts Candida albicans and Saccharomyces cerevisiae were studied. All three drugs had growth inhibitory effects. Significant effects on uridine uptake by all three drugs were seen, but inhibition of thymidine uptake was either small or non-existent. A marked stimulatory effect of all of the complexes on cell respiration was observed after 16 h growth in their presence. In some cases immediate stimulation of cellular respiration was invoked on drug treatment. The palladium complexes caused extensive mycelial growth of C. albicans whilst cisplatin induced pseudohyphal growth. Results are discussed with respect to possible mechanisms of action of the drugs.
研究了顺铂和两种可能具有癌症化疗价值的新型钯配合物对白色念珠菌和酿酒酵母的影响。这三种药物均有生长抑制作用。观察到所有三种药物对尿苷摄取均有显著影响，但对胸苷摄取的抑制作用很小或不存在。在其存在的情况下生长16小时后，观察到所有配合物对细胞呼吸均有明显的刺激作用。在某些情况下，药物处理后立即引起细胞呼吸的刺激。钯配合物导致白色念珠菌大量菌丝生长，而顺铂诱导假菌丝生长。针对药物可能的作用机制对结果进行了讨论。
