Department of Rheumatology, Yugawara Kosei-Nenkin Hospital, 438 Miyakami, Yugawara, Ashigara-shimo, Kanagawa 259-0396, Japan.
Mod Rheumatol. 2012 Apr;22(2):167-77. doi: 10.1007/s10165-011-0530-8. Epub 2011 Sep 28.
Osteoclasts are terminally differentiated multinucleated cells that are the principal resorptive cells of bone, playing a central role in the formation of the skeleton and regulation of its mass. The molecular events involved in the differentiation and function of osteoclasts had not been clarified for a long time. Over the past two decades, several novel approaches have been developed and adopted to investigate osteoclast biology. In the present review, we would like to update recent progress in the elucidation of the molecular mechanism of osteoclast activation and function.
破骨细胞是终末分化的多核细胞，是骨的主要吸收细胞，在骨骼形成和质量调节中发挥核心作用。很长一段时间以来，破骨细胞分化和功能涉及的分子事件都没有得到阐明。在过去的二十年中，已经开发并采用了几种新方法来研究破骨细胞生物学。在本综述中，我们希望更新阐明破骨细胞激活和功能的分子机制的最新进展。
