Department of Neuroradiology, Technische Universität München, Munich, Germany; Department of Neurology, Technische Universität München, München, Germany.
J Magn Reson Imaging. 2011 Dec;34(6):1295-302. doi: 10.1002/jmri.22788. Epub 2011 Sep 23.
To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique.
Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique.
Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique.
Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.
使用脉冲动脉自旋标记（PASL）技术，研究聚焦于颞叶和相关顶叶区域的与年龄相关的区域性灌注变化。
使用 3T 磁共振成像（MRI）技术，对 44 名健康志愿者（18 名男性，26 名女性；年龄范围 19 岁至 79 岁）的静息脑血流（CBF）图谱进行了脉冲动脉自旋标记（PASL）扫描。对 20 名受试者进行了重复测量，以确保所应用的 PASL 技术的可靠性和可重复性。
在顶叶皮质、楔前叶和尾状核中检测到与年龄相关的局灶性 CBF 下降，而在外侧和内侧颞叶（如海马、距状回和丘脑）中则出现 CBF 增加。此外，重复测量显示所应用的 PASL 技术具有较高的可靠性和可重复性。
这些数据为颞叶和顶叶在老化过程中灌注增加和减少的区域性分离模式提供了证据。
