Iannitelli Antonio, Grande Rossella, Di Stefano Antonio, Di Giulio Mara, Sozio Piera, Bessa Lucinda Janete, Laserra Sara, Paolini Cecilia, Protasi Feliciano, Cellini Luigina
Department of Drug Sciences, Faculty of Pharmacy; University G. d'Annunzio, Via dei Vestini 31, Chieti 66100, Italy; E-Mails:
Int J Mol Sci. 2011;12(8):5039-51. doi: 10.3390/ijms12085039. Epub 2011 Aug 8.
The ability to form biofilms contributes significantly to the pathogenesis of many microbial infections, including a variety of ocular diseases often associated with the biofilm formation on foreign materials. Carvacrol (Car.) is an important component of essential oils and recently has attracted much attention pursuant to its ability to promote microbial biofilm disruption. In the present study Car. has been encapsulated in poly(dl-lactide-co-glycolide (PLGA) nanocapsules in order to obtain a suitable drug delivery system that could represent a starting point for developing new therapeutic strategies against biofilm-associated infections, such as improving the drug effect by associating an antimicrobial agent with a biofilm viscoelasticity modifier.
形成生物膜的能力在许多微生物感染的发病机制中起着重要作用，包括多种眼部疾病，这些疾病通常与异物表面生物膜的形成有关。香芹酚（Car.）是精油的重要成分，最近因其促进微生物生物膜破坏的能力而备受关注。在本研究中，香芹酚被包裹在聚（dl-丙交酯-共-乙交酯）（PLGA）纳米胶囊中，以获得一种合适的药物递送系统，该系统可作为开发针对生物膜相关感染的新治疗策略的起点，例如通过将抗菌剂与生物膜粘弹性调节剂结合来提高药物效果。
