Mansour Heidi M, Sohn Minji, Al-Ghananeem Abeer, Deluca Patrick P
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA; E-Mails:
Int J Mol Sci. 2010 Sep 15;11(9):3298-322. doi: 10.3390/ijms11093298.
Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have led the way to the introduction of several marketed controlled release products and several more are in pre-clinical and clinical development.
控释给药适用于多种给药途径，与速释给药相比（如微粒和纳米粒）具有许多优势。这些优势包括给药频率降低、治疗控制更好、副作用更少，因此，这些剂型很受患者欢迎。高分子材料科学、颗粒工程设计、制造和纳米技术的进步推动了几种上市控释产品的推出，还有几种产品正处于临床前和临床开发阶段。
