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色氨酸拉链形成肽的五边形共轭物的合成与自组装行为

Syntheses and self-assembling behaviors of pentagonal conjugates of tryptophane zipper-forming peptide.

作者信息

Matsuura Kazunori, Murasato Kazuya, Kimizuka Nobuo

机构信息

Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka 819-0395, Japan; E-Mails:

出版信息

Int J Mol Sci. 2011;12(8):5187-99. doi: 10.3390/ijms12085187. Epub 2011 Aug 15.

DOI:10.3390/ijms12085187
PMID:21954352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3179159/
Abstract

Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversibly converted to nanoribbons by heating. In contrast, Pentagonal-Ala-Trpzip formed irregular aggregates in water.

摘要

合成了具有五氮杂环十五烷核心的色氨酸拉链形成肽（CKTWTWTE）的五边形共轭物（五边形-Gly-Trpzip和五边形-Ala-Trpzip），并研究了它们在水中的自组装行为。五边形-Gly-Trpzip在中性水（pH 7）中通过形成色氨酸拉链自组装成宽度约为5 nm的纳米纤维，通过加热不可逆地转变为纳米带。相比之下，五边形-Ala-Trpzip在水中形成不规则聚集体。

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