Goldstein I B, Shapiro D, Hui K K, Yu J L
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024-1759.
Psychosom Med. 1990 May-Jun;52(3):337-45. doi: 10.1097/00006842-199005000-00007.
Twenty young male coffee-drinkers consumed 150 mg of caffeine in decaffeinated coffee three times a day for 8 days. On days 3, 4, 7, and 8, caffeine or a placebo was administered in the laboratory at 11 A.M., 8 A.M., 11 A.M., and 8 A.M., respectively, in a randomized double-blind crossover design. There was a blood pressure increase relative to the placebo 45 min after taking caffeine at 8 A.M. (5.8/6.5 mm Hg). An increase of 2.4/5.2 mm Hg was seen with the second cup of coffee at 11 A.M. The lower the subject's pre-coffee serum caffeine level, the higher the systolic response, both at 8 A.M. (r = -0.60) and at 11 A.M. (r = -0.62). Because of the pressor effect resulting from habitual caffeine intake, the adverse implications of caffeine use should be considered.
20名年轻男性咖啡饮用者连续8天每天三次饮用含150毫克咖啡因的脱咖啡因咖啡。在第3、4、7和8天，采用随机双盲交叉设计，分别于上午11点、上午8点、上午11点和上午8点在实验室给予咖啡因或安慰剂。上午8点服用咖啡因后45分钟，血压相对于安慰剂有所升高（5.8/6.5毫米汞柱）。上午11点喝第二杯咖啡时血压升高了2.4/5.2毫米汞柱。无论是上午8点（r = -0.60）还是上午11点（r = -0.62），受试者咖啡前血清咖啡因水平越低，收缩压反应越高。由于习惯性摄入咖啡因会产生升压作用，因此应考虑咖啡因使用的不良影响。
