van Dusseldorp M, Smits P, Thien T, Katan M B
University of Nijmegen, Department of Medicine, The Netherlands.
Hypertension. 1989 Nov;14(5):563-9. doi: 10.1161/01.hyp.14.5.563.
The effect of decaffeinated versus regular coffee on blood pressure and heart rate was investigated. In a randomized double-blind, crossover trial, 45 healthy volunteers (23 women and 22 men, 25-45 years old) with a habitual intake of 4-6 cups coffee/day received 5 cups of regular coffee each day for a period of 6 weeks, and 5 cups of decaffeinated coffee for the next 6 weeks or vice versa. The background diet was kept constant. The total amount of caffeine ingested was 40 mg during the decaffeinated coffee period and 445 mg during the regular coffee period. Use of decaffeinated coffee led to a significant but small decrease in systolic (mean +/- SEM, -1.5 +/- 0.4 mm Hg; p = 0.002) and diastolic (-1.0 +/- 0.4 mm Hg; p = 0.017) ambulant blood pressure and to a small increase in ambulant heart rate (+1.3 +/- 0.6 beats/min; p = 0.031). Individual differences in rate of caffeine metabolism did not explain differences in long-term response of blood pressure to caffeine. We conclude that in normotensive adults replacement of regular by decaffeinated coffee leads to a real but small fall in blood pressure. However, it remains to be established whether a mass switch from regular to decaffeinated coffee would significantly reduce the total incidence of hypertension-related disorders.
研究了脱咖啡因咖啡与普通咖啡对血压和心率的影响。在一项随机双盲交叉试验中，45名健康志愿者（23名女性和22名男性，年龄25 - 45岁），习惯每天饮用4 - 6杯咖啡，他们每天饮用5杯普通咖啡，持续6周，接下来6周饮用5杯脱咖啡因咖啡，反之亦然。背景饮食保持不变。在饮用脱咖啡因咖啡期间摄入的咖啡因总量为40毫克，饮用普通咖啡期间为445毫克。饮用脱咖啡因咖啡导致收缩压（均值±标准误，-1.5±0.4毫米汞柱；p = 0.002）和舒张压（-1.0±0.4毫米汞柱；p = 0.017）的动态血压显著但小幅下降，动态心率小幅增加（+1.3±0.6次/分钟；p = 0.031）。咖啡因代谢率的个体差异并不能解释血压对咖啡因长期反应的差异。我们得出结论，在血压正常的成年人中，用脱咖啡因咖啡替代普通咖啡会导致血压实际但小幅下降。然而，常规咖啡向脱咖啡因咖啡的大规模转换是否会显著降低高血压相关疾病的总发病率仍有待确定。
