Amikishieva A V, Ilnitskaya S I, Nikolin V P, Popova N A
Institute of Cytology and Genetics of Siberian Department of Russian Academy of Sciences, Novosibirsk, Russian Federation 630090.
Exp Oncol. 2011 Sep;33(3):126-9.
To study the effect of new vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in the anxious adult male mice of C57Bl/6J strain. This type of receptors was thought to act as potential targets mediating the effect of negative psychoemotional state on tumor progression.
Anxiety-like psychoemotional state of the animals was produced using chronic social conflict model. Used behavioral tests were elevated plus-maze, social interaction test and open field test. Tumor cells were administrated on background of double or sixfold SSR149415 injections and the number of metastases in the lung were calculated 17 days later.
SSR149415 reduced the anxiety-like behavior measured in the elevated plus-maze and social interaction tests and did not affect locomotor activity in the open field test. Double and sixfold administration of the compound to such mice before and after inoculation of the tumor cells produced no effect on the metastasis rate.
vasopressin V1b receptor is involved in the mediation of anxious behavior of animals but is not involved in the mechanism underlying the influence of negative psychoemotional state on Lewis lung carcinoma metastasis.
研究新型血管加压素V1b受体拮抗剂SSR149415对C57Bl/6J品系成年雄性焦虑小鼠焦虑样行为及Lewis肺癌转移的影响。这类受体被认为是介导负性心理情绪状态对肿瘤进展影响的潜在靶点。
采用慢性社会冲突模型诱导动物产生焦虑样心理情绪状态。所使用的行为学测试包括高架十字迷宫、社会互动测试和旷场试验。在双倍或六倍剂量注射SSR149415的情况下接种肿瘤细胞，17天后计算肺内转移灶数量。
SSR149415降低了高架十字迷宫和社会互动测试中所测得的焦虑样行为，且未影响旷场试验中的运动活性。在接种肿瘤细胞前后对这类小鼠双倍和六倍剂量给药该化合物，对转移率均无影响。
血管加压素V1b受体参与介导动物的焦虑行为，但不参与负性心理情绪状态对Lewis肺癌转移影响的潜在机制。
