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[磷脂在儿茶酚胺作用实现中的作用]

[Role of phospholipids in the realization of catecholamine action].

作者信息

Pertseva M N, Zheludkova Z P

出版信息

Ukr Biokhim Zh (1978). 1978 Nov-Dec;50(6):701-5.

PMID:219571
Abstract

The involvement of phospholipids into the function of the hormonoreactive system realizing the catecholamine action on the skeletal muscle metabolism was studied at different stages of chicken ontogenetic development. The phospholipase "D" treatment of the chicken muscle homogenate removed the epinephrine activating effect on phosphorylase. Phosphatidylserine and phosphatidylinositol not only completely restore the epinephrine responsiveness of this system but also slightly intensify it. The cAMP and Ca2+ effects on muscle phosphorylase are also removed after the phospholipase "D" treatment. But they are not restored by phosphatidylserine and phosphatidylinositol. It is shown that these membrane phospholipids do not accelerate the origination of catecholamine reactivity of the above-mentioned hormonecompetent system in the process of embryonic development.

摘要

在鸡个体发育的不同阶段,研究了磷脂在实现儿茶酚胺对骨骼肌代谢作用的激素反应系统功能中的参与情况。用磷脂酶“D”处理鸡肌肉匀浆可消除肾上腺素对磷酸化酶的激活作用。磷脂酰丝氨酸和磷脂酰肌醇不仅能完全恢复该系统对肾上腺素的反应性,还能使其略有增强。磷脂酶“D”处理后,cAMP和Ca2+对肌肉磷酸化酶的作用也被消除。但磷脂酰丝氨酸和磷脂酰肌醇不能使其恢复。结果表明,这些膜磷脂在胚胎发育过程中不会加速上述激素感受系统儿茶酚胺反应性的产生。

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