Kuznetsova L A
Ontogenez. 1977;8(5):532-7.
The decrease of glycogen synthetase activity under the effect of Ca++ and cAMP is observed in the skeletal muscles of chick embryos only at the later stages of embryogenesis (15-18 days). In the cardiac muscle the activity of glycogen synthetase is inhibited by Ca++ apparently prior to the 12th day of development, long before the effect of cAMP which appears, as in the skeletal muscles, on the 18th day. Under the combined effect of cAMP and Ca++ in vitro and that of Ca++ and epinephrine in vivo, no additivity was observed. The possibility of Ca++ participation in the realization of catecholamine effect on the glycogen synthetase system of muscle and their interrelations with cAMP are discussed.
仅在胚胎发育后期（15 - 18天），才在鸡胚骨骼肌中观察到Ca++和cAMP作用下糖原合成酶活性的降低。在心肌中，糖原合成酶的活性显然在发育第12天之前就受到Ca++的抑制，这比cAMP的作用出现要早得多，cAMP的作用如同在骨骼肌中一样，在第18天出现。在体外cAMP和Ca++的联合作用以及体内Ca++和肾上腺素的联合作用下，未观察到相加作用。本文讨论了Ca++参与儿茶酚胺对肌肉糖原合成酶系统作用的实现及其与cAMP相互关系的可能性。
