Pereira Telmo, Maldonado João, Polónia Jorge, Alberto Silva José, Morais João, Marques Mário
Departamento de Cardiopneumologia, Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, Portugal.
Rev Port Cardiol. 2011 Sep;30(9):691-8. doi: 10.1016/S0870-2551(11)70011-7.
Aortic pulse wave velocity (PWV) has been associated with cardiovascular risk in different clinical subsets. This subanalysis of the EDIVA project aimed to establish criteria for normality of PWV based on a statistical definition that considers the fundamental physiological role of aging in arterial stiffness.
A sample of 668 healthy subjects (412 male) enrolled in the EDIVA Project (a prospective, multicenter, observational study) were studied. Mean age was 40.00 ± 13.42 years, body mass index was 25.90 ± 4.21kg/m(2), and systolic and diastolic blood pressure were respectively 125.47 ± 11.18 and 75.75 ± 9.27mmHg. PWV was determined annually using a Complior device, and mean follow-up was 23.3 ± 3.34 months. Personal and family history, physical examination, electrocardiogram and biochemical analysis were used to determine individual health.
In the overall population PWV was 8.8 ± 1.4m/sec, 8.7 ± 1.6m/sec in men and 8.9 ± 1.5m/sec in women (p=NS). Normal PWV was defined as the 95th percentile adjusted for age and gender, above which PWV was considered abnormal. Serial evaluation of PWV also enabled the annual age-dependent increase in PWV to be estimated at 5%, values above this cut-off being defined as abnormal vascular deterioration.
This study establishes criteria for normality based on a statistical definition that takes into account the fundamental physiological role of aging in arterial stiffness. Additionally, it provides a cut-off for the clinical interpretation of serial PWV measurements.
主动脉脉搏波速度（PWV）与不同临床亚组中的心血管风险相关。EDIVA项目的这项亚分析旨在基于一种统计定义来确定PWV的正常标准，该定义考虑了衰老在动脉僵硬度中的基本生理作用。
对纳入EDIVA项目（一项前瞻性、多中心、观察性研究）的668名健康受试者（412名男性）进行了研究。平均年龄为40.00±13.42岁，体重指数为25.90±4.21kg/m²，收缩压和舒张压分别为125.47±11.18和75.75±9.27mmHg。每年使用Complior设备测定PWV，平均随访时间为23.3±3.34个月。通过个人和家族史、体格检查、心电图和生化分析来确定个体健康状况。
在总体人群中，PWV为8.8±1.4m/秒，男性为8.7±1.6m/秒，女性为8.9±1.5m/秒（p值无统计学意义）。正常PWV定义为根据年龄和性别调整后的第95百分位数，高于此值的PWV被视为异常。对PWV的连续评估还能够估计出PWV每年随年龄增长的增加幅度为5%，高于此临界值的值被定义为异常的血管恶化。
本研究基于一种统计定义建立了正常标准，该定义考虑了衰老在动脉僵硬度中的基本生理作用。此外，它为连续PWV测量的临床解读提供了一个临界值。
