Koivistoinen T, Kööbi T, Jula A, Hutri-Kähönen N, Raitakari O T, Majahalme S, Kukkonen-Harjula K, Lehtimäki T, Reunanen A, Viikari J, Turjanmaa V, Nieminen T, Kähönen M
Department of Clinical Physiology, Medical School, University of Tampere, and Tampere University Hopsital, Tampere, Finland.
Clin Physiol Funct Imaging. 2007 May;27(3):191-6. doi: 10.1111/j.1475-097X.2007.00734.x.
The stiffening of arteries is associated with various cardiovascular diseases. Arterial stiffening can be studied utilizing arterial pulse wave velocity (PWV), but the absence of reliable reference values for PWV has limited its use in clinical practice. The aim of this study was to establish a range of reference values for PWV. PWV was examined by measuring the time difference of systolic pulse waves in arteries from the aortic arch to the popliteal artery using whole-body impedance cardiography (ICG). The study population consisted of 799 individuals (age range 25-76 years), 283 of whom had no evidence of cardiovascular disease, and a low burden of risk factors was selected to represent an apparently healthy population. In healthy study population, PWV was higher in males (8 x 9 +/- 1 x 8 m s(-1)) than females (8 x 1 +/- 2 x 0 m s(-1), P<0 x 001). Young males had lower PWV values than old males. Correspondingly, young females also had lower PWV values than old females. PWV was clearly associated with age, and PWV was higher in young and middle-aged males than in females. There was no statistically significant difference between old males and females in PWV. In conclusion, whole-body ICG provides a practical method for PWV measurement. Reference values can be useful in the clinical management of patients, especially in detecting early vascular disease or an increased risk of cardiovascular complications.
动脉僵硬度与多种心血管疾病相关。可利用动脉脉搏波速度（PWV）来研究动脉僵硬度，但缺乏PWV的可靠参考值限制了其在临床实践中的应用。本研究的目的是建立PWV的参考值范围。通过使用全身阻抗心动图（ICG）测量从主动脉弓到腘动脉的动脉收缩期脉搏波的时间差来检测PWV。研究人群包括799名个体（年龄范围25 - 76岁），其中283人无心血管疾病证据，且选择低风险因素负担的人群来代表明显健康的人群。在健康研究人群中，男性的PWV（8×9±1×8 m·s⁻¹）高于女性（8×1±2×0 m·s⁻¹，P<0×001）。年轻男性的PWV值低于老年男性。相应地，年轻女性的PWV值也低于老年女性。PWV与年龄明显相关，中青年男性的PWV高于女性。老年男性和女性的PWV无统计学显著差异。总之，全身ICG为PWV测量提供了一种实用方法。参考值在患者的临床管理中可能有用，特别是在检测早期血管疾病或心血管并发症风险增加方面。
