Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
Acta Neurochir (Wien). 2012 Jan;154(1):121-7. doi: 10.1007/s00701-011-1152-9. Epub 2011 Sep 30.
Previous publications have suggested a high correlation between flash visual evoked potential (F-VEP) N2 peak latency and intracranial pressure. This would enable F-VEP to be used as a non-invasive and inexpensive method to estimate ICP in a number of settings. However, basic knowledge about variability across subjects and test-retest properties of the F-VEP is lacking.
Fifteen healthy adult subjects were tested on three different occasions. F-VEP responses were recorded using international standards.
For the tested population, mean N2 latency was 65.7 ms (SD 10.7 ms) and the range was 48-110 ms. Intra-individual variability was high, in four of the 15 subjects more than 15 ms between testing sessions. The same was found for P2 latency and for N2 and P2 amplitudes. The response waveform was very variable and unambiguous marking of peaks was often difficult. One out of the 15 subjects had a very poorly developed F-VEP response, but a normal pattern-reversal VEP response.
F-VEP has a wide range of latency, amplitude and waveform across normal subjects. A large proportion of subjects also had a high intra-individual variability over time. This variability makes F-VEPs unreliable as a marker for intracranial pressure, and caution in interpreting F-VEP changes in clinical work is advised.
先前的出版物表明，闪光视觉诱发电位（F-VEP）N2 峰潜伏期与颅内压之间存在高度相关性。这将使 F-VEP 能够成为一种非侵入性且廉价的方法，在许多情况下用于估计 ICP。然而，关于受试者之间的变异性和 F-VEP 的测试-再测试特性的基本知识尚不清楚。
15 名健康成年受试者在三个不同的时间点接受了测试。使用国际标准记录 F-VEP 反应。
对于测试人群，N2 潜伏期的平均值为 65.7ms（SD 10.7ms），范围为 48-110ms。个体内变异性很高，在 15 名受试者中的 4 名中，测试之间的差异超过 15ms。P2 潜伏期以及 N2 和 P2 振幅也是如此。响应波形非常多变，峰的标记通常很困难。15 名受试者中的 1 名 F-VEP 反应非常不发达，但模式反转 VEP 反应正常。
F-VEP 在正常受试者中具有广泛的潜伏期、幅度和波形。很大一部分受试者在时间上也存在很大的个体内变异性。这种变异性使得 F-VEP 作为颅内压的标志物不可靠，因此在临床工作中解释 F-VEP 变化时应谨慎。
