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脑脊髓液引流装置与感染。全面综述。

Cerebrospinal fluid diversion devices and infection. A comprehensive review.

机构信息

Department of Neurosurgery, Clínico San Carlos University Hospital, Prof. Martin Lagos s/n, 28040, Madrid, Spain.

出版信息

Eur J Clin Microbiol Infect Dis. 2012 Jun;31(6):889-97. doi: 10.1007/s10096-011-1420-x. Epub 2011 Sep 30.

DOI:10.1007/s10096-011-1420-x
PMID:21960033
Abstract

Hydrocephalus is a common neurosurgical disease affecting approximately 40 per 100,000 people. Cerebrospinal fluid diversion devices are essential in the management of this pathology. These devices include internal shunts and external ventricular drains. Infection is the most significant complication resulting from the high frequency of appearance and the consequences it involves, since it is associated with increased morbidity and mortality. It also involves increased hospital costs (approximately 40,000 euro per episode). In the present report the authors make a comprehensive review of cerebrospinal fluid diversion devices and their most important complication: infection. The authors make special emphasis on the epidemiology, aetiology, pathogenesis, risk factors, symptoms and signs, diagnosis, treatment and prevention of infection.

摘要

脑积水是一种常见的神经外科疾病,影响约每 10 万人中有 40 人。脑脊液分流装置是这种病理的管理中必不可少的。这些装置包括内置分流器和外部脑室引流管。感染是最常见的并发症,也是最严重的并发症,因为它与发病率和死亡率的增加有关。它还涉及到更高的住院费用(每个病例约 40000 欧元)。在本报告中,作者对脑脊液分流装置及其最重要的并发症:感染进行了全面回顾。作者特别强调了感染的流行病学、病因学、发病机制、危险因素、症状和体征、诊断、治疗和预防。

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Tunneled antibiotic-impregnated vs. bolt-connected, non-coated external ventricular drainage: a comparison of complications.

本文引用的文献

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Do antibiotic-impregnated catheters prevent infection in CSF diversion procedures? Review of the literature.抗生素浸渍导管能否预防脑脊液分流术感染?文献复习。
J Infect. 2010 Jul;61(1):9-20. doi: 10.1016/j.jinf.2010.03.030. Epub 2010 Apr 2.
2
Antimicrobial suture wound closure for cerebrospinal fluid shunt surgery: a prospective, double-blinded, randomized controlled trial.抗菌缝线用于脑脊液分流手术伤口闭合:一项前瞻性、双盲、随机对照试验。
J Neurosurg Pediatr. 2008 Aug;2(2):111-7. doi: 10.3171/PED/2008/2/8/111.
3
Characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period.
带隧道的抗生素浸渍式与螺栓连接的无涂层外部脑室引流:并发症比较
Front Neurol. 2023 Aug 11;14:1202954. doi: 10.3389/fneur.2023.1202954. eCollection 2023.
4
Rapid Versus Gradual Weaning of External Ventricular Drain: A Systematic Literature Review and Meta-analysis.快速与逐渐撤离体外引流管:系统文献回顾和荟萃分析。
Neurocrit Care. 2023 Aug;39(1):250-259. doi: 10.1007/s12028-023-01766-6. Epub 2023 Jun 12.
5
Cerebrospinal Fluid System Infection in Children with Cancer: A Retrospective Analysis over 14 Years in a Major European Pediatric Cancer Center.癌症患儿的脑脊液系统感染:欧洲一家大型儿科癌症中心14年的回顾性分析
Antibiotics (Basel). 2022 Aug 17;11(8):1113. doi: 10.3390/antibiotics11081113.
6
Effect of a bundle approach on external ventricular drain-related infection.集束化策略对体外引流相关感染的影响。
Acta Neurochir (Wien). 2021 Apr;163(4):1135-1142. doi: 10.1007/s00701-020-04698-8. Epub 2021 Jan 11.
7
A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges.一项关于报告无炎症性脑膜重症患者脑脊液中抗生素药代动力学数据的研究的系统评价。
Antimicrob Agents Chemother. 2020 Dec 16;65(1). doi: 10.1128/AAC.01998-20.
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Antibiotic Distribution into Cerebrospinal Fluid: Can Dosing Safely Account for Drug and Disease Factors in the Treatment of Ventriculostomy-Associated Infections?抗生素向脑脊液中的分布:在治疗脑室相关性感染时,药物和疾病因素的剂量调整是否安全?
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Clin Infect Dis. 2008 Jul 1;47(1):73-82. doi: 10.1086/588298.
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J Neurosurg Pediatr. 2008 May;1(5):366-72. doi: 10.3171/PED/2008/1/5/366.
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J Neurosurg. 2007 Sep;107(3 Suppl):209-12. doi: 10.3171/PED-07/09/209.
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External ventricular drain infections are independent of drain duration: an argument against elective revision.体外脑室引流感染与引流持续时间无关:反对选择性翻修的观点。
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