Diederichs Antonia, Pawlik Evelyn, Barnbrock Anke, Schöning Stefan, Konczalla Jürgen, Finger Tobias, Lehrnbecher Thomas, Göttig Stephan, Bochennek Konrad
Division for Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, D-60596 Frankfurt, Germany.
Institute for Medical Microbiology and Infection Control, Johann Wolfgang Goethe-University, D-60596 Frankfurt, Germany.
Antibiotics (Basel). 2022 Aug 17;11(8):1113. doi: 10.3390/antibiotics11081113.
Infection of a cerebrospinal fluid system is a serious medical complication. We performed a retrospective monocentric analysis on temporary and permanent cerebrospinal fluid devices in children with and without cancer, covering a period of over 14 years. Between 2004 and 2017, 275 children with a cerebrospinal fluid system were seen at our institution. Thirty-eight children suffered from 51 microbiologically proven infectious episodes of the cerebrospinal fluid system (12 children with cancer and 26 children without cancer). Independently of the cerebrospinal fluid system used, the incidence of infection did not significantly differ between children with and without cancer and was the highest in children younger than one year. Infection occurred earlier in external ventricular drain (EVD) than ventriculoperitoneal (VP) shunt, and in EVD significantly earlier in children with cancer compared with patients without cancer. The pathogens isolated were mainly Gram-positive bacteria, in particular spp., which should be taken into account for empirical antimicrobial therapy.
脑脊液系统感染是一种严重的医学并发症。我们对有癌症和无癌症儿童的临时性和永久性脑脊液装置进行了一项为期超过14年的回顾性单中心分析。2004年至2017年期间，我们机构共诊治了275例脑脊液系统疾病患儿。38名儿童发生了51次经微生物学证实的脑脊液系统感染事件（12名患癌儿童和26名无癌儿童）。无论使用何种脑脊液系统，有癌症和无癌症儿童的感染发生率无显著差异，且在1岁以下儿童中最高。外引流（EVD）感染比脑室腹腔（VP）分流发生得更早，且患癌儿童的EVD感染比无癌患者显著更早发生。分离出的病原体主要是革兰氏阳性菌，尤其是 菌属，经验性抗菌治疗时应予以考虑。
