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接受静脉注射免疫球蛋白替代疗法的常见可变免疫缺陷患者血清的蛋白质组学分析。

Proteomic analysis of sera from common variable immunodeficiency patients undergoing replacement intravenous immunoglobulin therapy.

作者信息

Spadaro Giuseppe, D'Orio Concetta, Genovese Arturo, Galeotafiore Antonella, D'Ambrosio Chiara, Di Giovanni Stefano, Vitale Monica, Capasso Mario, Lamberti Vincenzo, Scaloni Andrea, Marone Gianni, Zambrano Nicola

机构信息

Dipartimento di Medicina Clinica, Scienze Cardiovascolari e Immunologiche e Centro Interdipartimentale di Ricerca in Immunologia di Base e Clinica, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131 Napoli, Italy.

出版信息

J Biomed Biotechnol. 2011;2011:706746. doi: 10.1155/2011/706746. Epub 2011 Sep 22.

DOI:10.1155/2011/706746
PMID:21960740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3180879/
Abstract

Common variable immunodeficiency is the most common form of symptomatic primary antibody failure in adults and children. Replacement immunoglobulin is the standard treatment of these patients. By using a differential proteomic approach based on 2D-DIGE, we examined serum samples from normal donors and from matched, naive, and immunoglobulin-treated patients. The results highlighted regulated expression of serum proteins in naive patients. Among the identified proteins, clusterin/ApoJ serum levels were lower in naive patients, compared to normal subjects. This finding was validated in a wider collection of samples from newly enrolled patients. The establishment of a cellular system, based on a human hepatocyte cell line HuH7, allowed to ascertain a potential role in the regulation of CLU gene expression by immunoglobulins.

摘要

常见变异型免疫缺陷是成人和儿童有症状的原发性抗体缺陷最常见的形式。替代免疫球蛋白是这些患者的标准治疗方法。通过使用基于二维差异凝胶电泳（2D-DIGE）的差异蛋白质组学方法，我们检测了正常供体以及匹配的初治、未接受过治疗和接受过免疫球蛋白治疗患者的血清样本。结果突出显示了初治患者血清蛋白的表达受到调节。在鉴定出的蛋白质中，与正常受试者相比，初治患者的簇集素/ApoJ血清水平较低。这一发现在更多新入组患者的样本中得到了验证。基于人肝癌细胞系HuH7建立的细胞系统，有助于确定免疫球蛋白在调节CLU基因表达中的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e0/3180879/d208508b3734/JBB2011-706746.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e0/3180879/632fd98abdad/JBB2011-706746.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e0/3180879/f017db5236cd/JBB2011-706746.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e0/3180879/d208508b3734/JBB2011-706746.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e0/3180879/632fd98abdad/JBB2011-706746.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e0/3180879/f017db5236cd/JBB2011-706746.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e0/3180879/d208508b3734/JBB2011-706746.003.jpg

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本文引用的文献

1
Clinical and immunological analysis of 23 adult patients with common variable immunodeficiency.23 例成人普通变异性免疫缺陷的临床和免疫学分析。
J Investig Allergol Clin Immunol. 2010;20(3):222-36.
2
Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency.FcRn 表达与常见变异性免疫缺陷患者肺部异常和 IVIG 代谢之间的关系。
Clin Immunol. 2010 Sep;136(3):419-25. doi: 10.1016/j.clim.2010.05.006.
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How I treat common variable immune deficiency.我是如何治疗常见可变免疫缺陷的。
Blood. 2010 Jul 8;116(1):7-15. doi: 10.1182/blood-2010-01-254417. Epub 2010 Mar 23.
4
Frequency of Treg cells is reduced in CVID patients with autoimmunity and splenomegaly and is associated with expanded CD21lo B lymphocytes.CVID 伴自身免疫和脾肿大患者 Treg 细胞频率降低，与扩增的 CD21lo B 淋巴细胞有关。
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Chapter 8: Clusterin: A multifacet protein at the crossroad of inflammation and autoimmunity.第八章：簇集蛋白：炎症和自身免疫的十字路口的多功能蛋白。
Adv Cancer Res. 2009;104:139-70. doi: 10.1016/S0065-230X(09)04008-1.
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Chapter 7: Cell protective functions of secretory Clusterin (sCLU).第七章：分泌型簇集素（sCLU）的细胞保护功能。
Adv Cancer Res. 2009;104:115-38. doi: 10.1016/S0065-230X(09)04007-X.
7
Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding.第六章：Clusterin 的伴侣作用及其在细胞外蛋白质折叠质量控制中的假定作用。
Adv Cancer Res. 2009;104:89-114. doi: 10.1016/S0065-230X(09)04006-8.
8
Autoimmunity in common variable immunodeficiency.普通可变免疫缺陷中的自身免疫
Curr Allergy Asthma Rep. 2009 Sep;9(5):347-52. doi: 10.1007/s11882-009-0051-0.
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B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans.B细胞活化因子受体缺陷与人类成人期抗体缺陷综合征相关。
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13945-50. doi: 10.1073/pnas.0903543106. Epub 2009 Aug 6.
10
Common variable immunodeficiency: etiological and treatment issues.常见变异性免疫缺陷：病因与治疗问题。
Int Arch Allergy Immunol. 2009;150(4):311-24. doi: 10.1159/000226232. Epub 2009 Jul 1.