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本文引用的文献

1
Severe hypertriglyceridemia influenced by alcohol (SHIBA).酒精影响的严重高甘油三酯血症（SHIBA）。
Alcohol Alcohol. 2011 Mar-Apr;46(2):113-6. doi: 10.1093/alcalc/agq088. Epub 2011 Jan 17.
2
Effects of ethanol intake on lipoproteins and atherosclerosis.乙醇摄入对脂蛋白和动脉粥样硬化的影响。
Curr Opin Lipidol. 2010 Aug;21(4):346-51. doi: 10.1097/MOL.0b013e32833c1f41.
3
Alcohol and cardiovascular mortality: common sense and scientific truth.酒精与心血管疾病死亡率：常识与科学真相
J Am Coll Cardiol. 2010 Mar 30;55(13):1336-8. doi: 10.1016/j.jacc.2009.10.057.
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Positive relationship between dietary fat, ethanol intake, triglycerides, and hypothalamic peptides: counteraction by lipid-lowering drugs.膳食脂肪、乙醇摄入量、甘油三酯与下丘脑肽之间的正相关关系：降脂药物的对抗作用。
Alcohol. 2009 Sep;43(6):433-41. doi: 10.1016/j.alcohol.2009.07.003.
5
Cardiovascular risk is more related to drinking pattern than to the type of alcoholic drinks.心血管风险与饮酒模式的关系比与酒精饮料类型的关系更大。
Neth J Med. 2008 Dec;66(11):467-73.
6
Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice.在给小鼠注射乙醇之前喂食鱼油可预防急性乙醇诱导的脂肪肝。
J Hepatol. 2008 Sep;49(3):441-50. doi: 10.1016/j.jhep.2008.04.026. Epub 2008 Jun 11.
7
Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver.乙醇摄入通过降低大鼠肝脏中AMP激活的蛋白激酶活性来损害脂肪酸代谢的调节。
Biochimie. 2008 Mar;90(3):460-6. doi: 10.1016/j.biochi.2007.09.019. Epub 2007 Oct 5.
8
Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC study.饮酒量及饮用酒精饮料类型与血浆脂质水平的关系：动脉粥样硬化风险社区研究中白人和非裔美国人的差异
Ann Epidemiol. 2008 Feb;18(2):101-7. doi: 10.1016/j.annepidem.2007.07.103. Epub 2007 Sep 14.
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Clinical practice. Hypertriglyceridemia.临床实践。高甘油三酯血症。
N Engl J Med. 2007 Sep 6;357(10):1009-17. doi: 10.1056/NEJMcp070061.
10
Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation.大鼠白色脂肪组织中慢性乙醇与甘油三酯周转：慢性乙醇摄入后胰岛素抗脂解作用的抑制导致甘油三酯降解增加。
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酒精对餐后及空腹甘油三酯的影响。

The effect of alcohol on postprandial and fasting triglycerides.

作者信息

Van de Wiel Albert

机构信息

Department of Internal Medicine, Meander Medical Center, Utrechtseweg 160, 3818 ES Amersfoort, The Netherlands.

出版信息

Int J Vasc Med. 2012;2012:862504. doi: 10.1155/2012/862504. Epub 2011 Sep 22.

DOI:10.1155/2012/862504
PMID:21961068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3179875/
Abstract

Alcohol has a significant additive effect on the postprandial triglyceride peak when it accompanies a meal containing fat, especially saturated fat. This results from a decrease in the breakdown of chylomicrons and VLDL remnants due to an acute inhibitory effect of alcohol on lipoprotein lipase activity. Furthermore, alcohol increases the synthesis of large VLDL particles in the liver, which is the main source of triglycerides in the hypertriglyceridemia associated with chronic excessive alcohol intake. In case of chronic consumption, lipoprotein lipase activity seems to adapt itself. The effect of alcohol on adipose tissues is less clear. Sometimes, a severe hypertriglyceridemia induced by alcohol (SHIBA) can be observed, especially in patients with type 2 diabetes mellitus and/or obesity increasing the risk of pancreatitis.

摘要

当酒精与含有脂肪（尤其是饱和脂肪）的餐食同时摄入时，它对餐后甘油三酯峰值具有显著的相加作用。这是由于酒精对脂蛋白脂肪酶活性的急性抑制作用，导致乳糜微粒和极低密度脂蛋白（VLDL）残粒的分解减少所致。此外，酒精会增加肝脏中大型VLDL颗粒的合成，而肝脏是与慢性过量饮酒相关的高甘油三酯血症中甘油三酯的主要来源。在长期饮酒的情况下，脂蛋白脂肪酶活性似乎会自行适应。酒精对脂肪组织的影响尚不清楚。有时，可观察到酒精诱发的严重高甘油三酯血症（SHIBA），尤其是在2型糖尿病和/或肥胖患者中，这会增加胰腺炎的风险。