酒精对餐后及空腹甘油三酯的影响。
The effect of alcohol on postprandial and fasting triglycerides.
作者信息
Van de Wiel Albert
机构信息
Department of Internal Medicine, Meander Medical Center, Utrechtseweg 160, 3818 ES Amersfoort, The Netherlands.
出版信息
Int J Vasc Med. 2012;2012:862504. doi: 10.1155/2012/862504. Epub 2011 Sep 22.
Abstract
Alcohol has a significant additive effect on the postprandial triglyceride peak when it accompanies a meal containing fat, especially saturated fat. This results from a decrease in the breakdown of chylomicrons and VLDL remnants due to an acute inhibitory effect of alcohol on lipoprotein lipase activity. Furthermore, alcohol increases the synthesis of large VLDL particles in the liver, which is the main source of triglycerides in the hypertriglyceridemia associated with chronic excessive alcohol intake. In case of chronic consumption, lipoprotein lipase activity seems to adapt itself. The effect of alcohol on adipose tissues is less clear. Sometimes, a severe hypertriglyceridemia induced by alcohol (SHIBA) can be observed, especially in patients with type 2 diabetes mellitus and/or obesity increasing the risk of pancreatitis.
摘要
当酒精与含有脂肪（尤其是饱和脂肪）的餐食同时摄入时，它对餐后甘油三酯峰值具有显著的相加作用。这是由于酒精对脂蛋白脂肪酶活性的急性抑制作用，导致乳糜微粒和极低密度脂蛋白（VLDL）残粒的分解减少所致。此外，酒精会增加肝脏中大型VLDL颗粒的合成，而肝脏是与慢性过量饮酒相关的高甘油三酯血症中甘油三酯的主要来源。在长期饮酒的情况下，脂蛋白脂肪酶活性似乎会自行适应。酒精对脂肪组织的影响尚不清楚。有时，可观察到酒精诱发的严重高甘油三酯血症（SHIBA），尤其是在2型糖尿病和/或肥胖患者中，这会增加胰腺炎的风险。
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2
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3
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4
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5
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Neth J Med. 2008 Dec;66(11):467-73.
6
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7
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Biochimie. 2008 Mar;90(3):460-6. doi: 10.1016/j.biochi.2007.09.019. Epub 2007 Oct 5.
8
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9
Clinical practice. Hypertriglyceridemia.临床实践。高甘油三酯血症。
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10
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