Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands.
Alcohol Alcohol. 2011 Mar-Apr;46(2):113-6. doi: 10.1093/alcalc/agq088. Epub 2011 Jan 17.
This study was conducted to examine the relationship between triglyceride (TG) levels and a history of excessive drinking in patients with severe hypertriglyceridemia (HT).
Alcohol intake as well as other risk factors associated with HT were searched for in case records of 300 patients known to the laboratory to have had a TG level over 11.3 mmol/l.
The majority of severe HT could be attributed to obesity, diabetes mellitus, excessive alcohol consumption or combinations of these. Excessive alcohol intake (over 210 g/week for males; over 140 g/week for females) was recorded for 24% of the total, and for 43% in the highest TG quartile. TG levels were significantly higher in the excessive drinkers (P < 0.001) and in patients with acute pancreatitis (P = 0.001). The incidence of pancreatitis in this cohort was 4% and limited to very high TG levels.
Excessive alcohol consumption was recorded in a quarter of patients with severe HT. Patients with the combination of obesity, diabetes and alcohol excess are prone to develop extremely high TG values.
本研究旨在探讨严重高甘油三酯血症（HT）患者的甘油三酯（TG）水平与过量饮酒史之间的关系。
在已知实验室 TG 水平超过 11.3mmol/L 的 300 名患者的病历中，寻找与 HT 相关的酒精摄入以及其他风险因素。
大多数严重 HT 可归因于肥胖、糖尿病、过量饮酒或这些因素的组合。过量饮酒（男性每周超过 210 克；女性每周超过 140 克）占总人数的 24%，在 TG 四分位最高的患者中占 43%。过量饮酒者的 TG 水平显著升高（P<0.001），且急性胰腺炎患者的 TG 水平也显著升高（P=0.001）。在本队列中，胰腺炎的发生率为 4%，且仅限于极高的 TG 水平。
在四分之一的严重 HT 患者中记录到了过量饮酒。肥胖、糖尿病和酒精过量并存的患者容易出现极高的 TG 值。
