Kurnjek M L, Trolliet M R, Mikulic L, Basso N
Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Clin Exp Hypertens A. 1990;12(4):631-45. doi: 10.3109/10641969009073489.
Previous investigations have shown that depletion of brain norepinephrine (NE) induced by chemical sympathectomy resulted in significant changes in the central renin-angiotensin system. The purpose of the present work was to increase the NE concentration in the central nervous system (CNS) in order to analyze its effect on the peptidergic complex and on the blood pressure (BP) levels. Treated rats were given the following drugs in the drinking water: 1-dopa (12 mg/rat/day), carbidopa (6 mg/rat/day) and pargyline (10 mg/rat/day) during 25 days. BP was determined, blood and cerebrospinal fluid (CSF) samples were obtained. The CNS was dissected into several areas. NE, angiotensinogen (AoC) and renin concentration (RC) were determined in the brain parenchyma; AoC was evaluated in CSF and plasma samples. Pharmacological treatment resulted in an hypotensive effect and, at the same time, an increase of NE in the CNS (about 100%; p less than 0.0005). These changes were accompanied by a significant decrease in the peripheral and central AoC. These results add new evidence to the postulated relationship between these two important regulatory systems involved in cardiovascular control.
先前的研究表明，化学性交感神经切除术诱导的脑去甲肾上腺素（NE）耗竭会导致中枢肾素-血管紧张素系统发生显著变化。本研究的目的是提高中枢神经系统（CNS）中的NE浓度，以分析其对肽能复合物和血压（BP）水平的影响。给处理组大鼠在饮水中给予以下药物：左旋多巴（12mg/大鼠/天）、卡比多巴（6mg/大鼠/天）和帕吉林（10mg/大鼠/天），持续25天。测定血压，采集血液和脑脊液（CSF）样本。将CNS解剖成几个区域。测定脑实质中的NE、血管紧张素原（AoC）和肾素浓度（RC）；在CSF和血浆样本中评估AoC。药物治疗产生了降压作用，同时CNS中的NE增加（约100%；p<0.0005）。这些变化伴随着外周和中枢AoC的显著降低。这些结果为这两个参与心血管控制的重要调节系统之间的假定关系增添了新的证据。
