去负荷大鼠股骨中的膳食盐、骨强度和矿物质含量

Dietary salt, bone strength, and mineral content in unloaded rat femurs.

作者信息

Liang Michael T C, Navidi Meena, Cleek Tammy M, Arnaud Sara B

机构信息

Life Sciences Division, NASA Ames Research Center, Moffett Field, CA, USA.

出版信息

Aviat Space Environ Med. 2011 Oct;82(10):941-5. doi: 10.3357/asem.2967.2011.

DOI:10.3357/asem.2967.2011

PMID:21961397

Abstract

INTRODUCTION

Reduced bone mineral and ultimate strength are regular consequences of unloading bone. The aim of this study was to determine if high dietary salt intake would reduce the bone density and strength to a greater extent in rats with unloaded bones compared to ambulatory control rats fed the same dietary calcium and phosphorus.

METHODS

Mature male Sprague-Dawley rats were divided into four groups: two exposed to a spaceflight model that unloaded the hind limbs (HU) and two controls (C) with normal ambulation. Half the HU and C rats were fed normal dietary salt (0.26%, NNa) and half high dietary salt (8%, HNa). The calcium (Ca) and phosphorus (P) content of the diets was normal (Ca 0.5% and P 0.6%) in all four groups. After 4 wk of hind limb unloading, the bone mineral content (BMC) of excised femurs was measured by the ash weight and the ultimate torsional strength was determined by a torsional strength test device.

RESULTS

Femoral BMC (mg) was lower in HUNNa than C rats fed normal salt diets. Femurs from HU rats fed normal salt diets showed lower (20-26%) torsional strength (Nmm), compared to all other groups.

DISCUSSION

It appears that high salt diets with normal amounts of calcium and phosphorus may prevent the decrease in bone torsional strength and BMC induced by unloading the femurs in 6-mo-old rats.

摘要

引言

骨矿物质减少和极限强度降低是骨骼失载的常见后果。本研究的目的是确定与摄入相同膳食钙和磷的正常活动对照大鼠相比，高盐饮食是否会在骨骼失载的大鼠中更大程度地降低骨密度和强度。

方法

将成年雄性Sprague-Dawley大鼠分为四组：两组暴露于使后肢失载的太空飞行模型（HU），两组为正常活动的对照组（C）。HU组和C组大鼠各有一半喂食正常膳食盐（0.26%，NNa），另一半喂食高膳食盐（8%，HNa）。所有四组日粮中的钙（Ca）和磷（P）含量均正常（Ca 0.5%，P 0.6%）。后肢失载4周后，通过骨灰重量测量切除股骨的骨矿物质含量（BMC），并通过扭转强度测试装置测定极限扭转强度。