Koneva N A, Il'enko V I
Vopr Virusol. 1978 Jul-Aug(4):417-22.
An experimental model of associated influenza-parainfluenza infection has been developed. Simultaneous inoculation of mice with influenza A2/21/65 and parainfluenza type 3 or inoculation with these viruses at an interval of 24 hours was shown to produce a considerably more severe disease as manifested by the development of severe confluent pneumonias involving both lungs and death of the inoculated animals. The animals with the associated infection showed no significant difference in antibody titers or the intensity of immunity as compared with control groups (influenza or parainfluenza monoinfection). The development of the mixed infection was accompanied by the inhibition of neutrophilic and macrophage phagocytosis and inhibition of interferon production.
已建立了一种甲型流感病毒和副流感病毒联合感染的实验模型。研究表明，对小鼠同时接种A2/21/65甲型流感病毒和3型副流感病毒，或在24小时间隔内接种这两种病毒，会引发严重得多的疾病，表现为双侧肺部出现严重融合性肺炎，接种动物死亡。与对照组（甲型流感或副流感单一感染）相比，联合感染的动物在抗体滴度或免疫强度方面没有显著差异。混合感染的发展伴随着中性粒细胞和巨噬细胞吞噬作用的抑制以及干扰素产生的抑制。
