Boldasov V K, Kalinina N A, Revunova O V, Guseva V M, Leonov V M, Sukhinin V P, Il'enko V I
Vopr Virusol. 1991 Sep-Oct;36(5):389-92.
Deitiforin in HEp-2 cell culture was shown to inhibit replication of the reference PIV-3 strain when administered 1 hour before virus inoculation. The most marked effect of the drug was observed in the first 4 days of observation. In experimental newborn mice infected with parainfluenza virus 3 deitiforin protected the animals from developing the infection. In humans given deitiforin reaction to vaccination was found to develop 5-6 times more rarely than in the control group, PIV-3 could be isolated twice as rarely, and a diagnostically significant rise of specific antibody levels was observed less frequently.
在HEp-2细胞培养中，当在病毒接种前1小时给药时，地替福林被证明可抑制参考PIV-3毒株的复制。在观察的前4天观察到该药物的最显著效果。在感染副流感病毒3的新生实验小鼠中，地替福林可保护动物不发生感染。在给予地替福林的人中，发现接种疫苗后的反应发生频率比对照组低5至6倍，分离出PIV-3的频率低两倍，并且特异性抗体水平的诊断性显著升高较少见。
