[Change in the level of immunoglobulins A in the intestines of children after administration of live trivalent poliomyelitis vaccine by different methods].

It was shown that titers of the neutralizing activity of fecal extracts (coproantibody, CA) to poliomyelitis virus type II in the course of four administrations of live trivalent poliovaccine in drops directly into the mouth and in capsules were higher than CA titers to poliomyelitis virus types I and III. Particularly low CA titers to poliovirus types I and III were in children given the vaccine in the capsule, that is directly into the gastro-intestinal tract. Accordingly IgA levels in fecal extracts in this group of children were lower than in those given the vaccine in drops. In children of both groups no IgG of IgM (0.24 IU/ml) could be found in fecal extracts.