Barnes J M, Galbraith N S
Bull World Health Organ. 1966;34(5):693-9.
In view of certain difficulties involved in the administration of poliomyelitis vaccine in liquid form on sugar or in syrup in mass campaigns, trials have been conducted with a new single-dose preparation of live attenuated poliovaccine (Sabin strain) in an emulsion in a gelatin capsule. Each capsule contained a standard dose of vaccine which was shown to be stable in this form. It has been demonstrated that the capsule vaccine was as effective as liquid vaccine both in children and in adults. The capsules were acceptable to adults and children over the age of 5 years, but between 6% and 7% of 4-5-year-old children refused the vaccine in this form owing to difficulty in swallowing the capsules.The authors consider that the capsule may be recommended for the routine immunization of older children and adults and for mass vaccination campaigns. It is suggested that the vaccine could be administered to young children and babies in the course of such campaigns by opening the capsule and mixing the contents with water or sweetened liquid in a spoon.
鉴于在大规模疫苗接种运动中，以糖或糖浆形式服用液体脊髓灰质炎疫苗存在一定困难，因此对一种新的单剂量减毒活脊髓灰质炎疫苗（萨宾株）明胶胶囊乳剂进行了试验。每个胶囊含有标准剂量的疫苗，且已证明这种形式的疫苗是稳定的。已证明胶囊疫苗在儿童和成人中与液体疫苗一样有效。5岁以上的儿童和成人都接受这种胶囊，但4至5岁的儿童中有6%至7%因吞咽胶囊困难而拒绝服用这种形式的疫苗。作者认为，这种胶囊可推荐用于较大儿童和成人的常规免疫以及大规模疫苗接种运动。建议在这类运动中，可通过打开胶囊并将其内容物与勺子中的水或甜味液体混合，给幼儿和婴儿接种疫苗。
