Karabulut Aysun, Demirlenk Semra, Sevket Osman
Department of Obstetrics and Gynecology and Department of Radiology, Denizli State Hospital, Denizli, Turkey.
Gynecol Endocrinol. 2012 Apr;28(4):245-8. doi: 10.3109/09513590.2011.613971. Epub 2011 Oct 1.
To evaluate the effects of ethinyl estradiol-cyproterone acetate (EE-CA) treatment on metabolic and cardiovascular risk factors, and body fat distribution in polycystic ovary syndrome (PCOS) after 6-month treatment.
Thirty women with PCOS were evaluated before and after 6 months of EE-CA treatment. Anthropometrical measurements, hormonal levels, lipid and glucose profile were evaluated. Body fat thickness in four regions and carotid intima media thickness (IMT) were measured. Interval change in antropometric measurements, glucose and lipid profile, carotid IMT and body fat distribution was evaluated before and after 6-month EE-CA treatment.
Ferriman-Gallwey score and serum testosterone levels were significantly decreased after EE-CA treatment (p < 0.01). No significant effect was detected on insulin resistance, lipid profile and carotid artery IMT. The visceral, subcutaneous and preperitoneal fat thicknesses decreased, and mid-thigh fat thickness increased after treatment period. However, only the alteration in subcutaneous fat thickness achieved a statistical significance (p < 0.01).
The EE-CA is an effective regimen in treatment of hirsutism and menstrual regulation. Although it provides significant decrease in subcutaneous fat thickness after 6-month treatment, it has no beneficial effect with respect to visceral fat thickness, metabolic and cardiovascular risk factors.
评估炔雌醇环丙孕酮（EE-CA）治疗6个月后对多囊卵巢综合征（PCOS）患者代谢和心血管危险因素以及体脂分布的影响。
对30例PCOS女性患者在接受EE-CA治疗6个月前后进行评估。评估人体测量学指标、激素水平、血脂和血糖情况。测量四个区域的体脂厚度以及颈动脉内膜中层厚度（IMT）。评估接受6个月EE-CA治疗前后人体测量学指标、血糖和血脂情况、颈动脉IMT以及体脂分布的变化情况。
EE-CA治疗后费里曼-盖尔维评分和血清睾酮水平显著降低（p < 0.01）。未检测到对胰岛素抵抗、血脂情况和颈动脉IMT有显著影响。治疗期间，内脏、皮下和腹膜前脂肪厚度降低，大腿中部脂肪厚度增加。然而，只有皮下脂肪厚度的改变具有统计学意义（p < 0.01）。
EE-CA是治疗多毛症和调节月经的有效方案。尽管在6个月治疗后皮下脂肪厚度显著降低，但对内脏脂肪厚度、代谢和心血管危险因素并无有益影响。
