Karakurt Feridun, Carlioglu Ayse, Kaygusuz Ikbal, Gumus Ilknur Inegöl, Uz Burak, Akdeniz Derya
Department of Endocrinology, Faculty of Medical School, Turgut Ozal University, Ankara, Turkey.
Arch Gynecol Obstet. 2014 Jan;289(1):135-40. doi: 10.1007/s00404-013-2960-3. Epub 2013 Jul 24.
Our study was undertaken to evaluate the levels of asymmetric dimethyl-arginine (ADMA) in a group of patients affected with polycystic ovary syndrome (PCOS)--under ethinyl estradiol-cyproterone acetate treatment or not--as compared with a group of healthy controls.
Fifty-eight women with PCOS and 45 patients as control group were included in the study. The 58 women with PCOS were separated into two groups: Group A (n = 29) were treated with an oral contraceptive pill containing 0.035 mg of ethinyl estradiol (EE) and 2 mg of cyproterone acetate (CA) (Diane-35) for 6 months. Group B (n = 29) did not take any drug. Group C (n = 45) was healthy women as control group. Serum levels of ADMA, lipid and glucose metabolism parameters, hormone profile were measured on the sixth month of treatment.
ADMA levels were similar in women with PCOS and controls, whereas ADMA levels significantly decreased after a period of 6 months treatment with EE + CA in women with PCOS. ADMA levels and insulin resistance were decreased with treatment. However, patients with PCOS had significantly higher total cholesterol and Low-density lipoprotein cholesterol (LDL-C) compared to controls, treatment with EE + CA did not provide any improvement on lipid parameters.
Serum ADMA levels and insulin resistance were lower in PCOS group treated with EE + CA than control group.
我们开展这项研究是为了评估一组多囊卵巢综合征（PCOS）患者（无论是否接受炔雌醇 - 醋酸环丙孕酮治疗）与一组健康对照者相比的不对称二甲基精氨酸（ADMA）水平。
本研究纳入了58例PCOS女性患者和45例作为对照组的患者。58例PCOS女性患者被分为两组：A组（n = 29）接受含有0.035 mg炔雌醇（EE）和2 mg醋酸环丙孕酮（CA）的口服避孕药（达英 - 35）治疗6个月。B组（n = 29）未服用任何药物。C组（n = 45）为健康女性作为对照组。在治疗的第6个月测量血清ADMA水平、脂质和葡萄糖代谢参数、激素谱。
PCOS女性患者和对照组的ADMA水平相似，而PCOS女性患者接受EE + CA治疗6个月后ADMA水平显著降低。治疗后ADMA水平和胰岛素抵抗降低。然而，PCOS患者的总胆固醇和低密度脂蛋白胆固醇（LDL - C）显著高于对照组，EE + CA治疗对脂质参数没有任何改善。
接受EE + CA治疗的PCOS组血清ADMA水平和胰岛素抵抗低于对照组。
