Department of Otolaryngology-Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
Am J Otolaryngol. 2012 Mar-Apr;33(2):239-43. doi: 10.1016/j.amjoto.2011.07.005. Epub 2011 Sep 29.
The aim of this study was to investigate changes in vocal symptoms in relation to estrogen level in women undergoing in vitro fertilization.
A total of 31 women were enrolled in this study. The following vocal symptoms were investigated: vocal tiring or fatigue, vocal straining, throat clearing, lump sensation, hoarseness, and aphonia (or loss of voice). The severity of these symptoms was graded from 0 to 4, where 0 means absence of the symptom and 3 means severe symptom presence. The frequency of these symptoms was evaluated in the first visit at presentation; second visit, 4 to 5 days after ovarian stimulation; and third visit, 8 to 10 days after stimulation. In the second and third visits, the estradiol levels were measured.
The mean age was 32.33 ± 4.80 years. Ten of the 31 patients had at least 1 vocal symptom. The most common vocal symptom in all 3 visits was throat clearing, with an incidence of 22.6% in the first and second visits and 19.4% in the third visit. This was followed by vocal fatigue or tiring and lump sensation, with an incidence of 9.68% for both. The incidence of all the vocal symptoms as well as their severity did not change throughout the visits, except for throat clearing, which has decreased in the third visit but not significantly (22.6% vs 19.4%, P = 1). Subjects with vocal symptoms had lower estradiol level compared with those with no vocal symptoms; however, the difference was not statistically significant (P = .108 and .267, respectively).
Subjects undergoing in vitro fertilization do not experience changes in their vocal symptoms when present, except for throat clearing. However, those with vocal symptoms have lower levels of estradiol compared with those with no vocal symptoms.
本研究旨在探讨接受体外受精的女性中与雌激素水平相关的嗓音症状变化。
共纳入 31 名女性。研究人员调查了以下嗓音症状：发声疲劳或疲劳、发声费力、清嗓、咽喉异物感、声音嘶哑和失音（或声音丧失）。这些症状的严重程度从 0 级到 4 级进行分级，其中 0 级表示无症状，3 级表示症状严重。在首次就诊时评估这些症状的频率；第二次就诊，在卵巢刺激后 4 到 5 天；第三次就诊，在刺激后 8 到 10 天。在第二次和第三次就诊时，测量雌二醇水平。
患者的平均年龄为 32.33±4.80 岁。31 名患者中有 10 名至少存在 1 种嗓音症状。在所有 3 次就诊中，最常见的嗓音症状是清嗓，首次和第二次就诊的发生率为 22.6%，第三次就诊的发生率为 19.4%。其次是发声疲劳或发声费力和咽喉异物感，发生率均为 9.68%。除清嗓外，所有嗓音症状及其严重程度在整个就诊过程中均未发生变化，而清嗓在第三次就诊时有所减少，但无统计学意义（22.6%比 19.4%，P=1）。有嗓音症状的患者雌二醇水平低于无嗓音症状的患者；然而，差异无统计学意义（分别为 P=.108 和.267）。
接受体外受精的患者中，除清嗓外，目前不存在嗓音症状变化。然而，有嗓音症状的患者雌二醇水平低于无嗓音症状的患者。
