Leone M, Frediani F, Patruno G, Valentini S, Bussone G
Headache Centre, C. Besta Neurological Institute, Milano, Italy.
Headache. 1990 May;30(6):363-5. doi: 10.1111/j.1526-4610.1990.hed3006363.x.
Nimodipine is one of the most discussed calcium antagonists used in cerebrovascular diseases and, recently, in migraine prophylaxis. Its specificity in preventing cerebral arterial constriction has been invoked to explain nimodipine's efficacy in migraine. The discovery of neuronal receptors specific for dihydropyridines, however, favours a mechanism of action for nimodipine that is not exclusively vascular. This is in accordance with a view of migraine pathogenesis which implicates a primary neuronal event as the basis of the vascular changes observed in migraine patients.
尼莫地平是脑血管疾病中讨论最多的钙拮抗剂之一，最近也用于偏头痛预防。人们认为其预防脑动脉收缩的特异性可解释尼莫地平在偏头痛中的疗效。然而，二氢吡啶特异性神经元受体的发现，支持尼莫地平的作用机制并非完全是血管性的。这与偏头痛发病机制的观点一致，即偏头痛发病机制认为原发性神经元事件是偏头痛患者观察到的血管变化的基础。
