Center for Neural Circuits and Behavior, Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093, USA.
Curr Opin Neurobiol. 2012 Jun;22(3):559-63. doi: 10.1016/j.conb.2011.09.001. Epub 2011 Sep 29.
Since the initial findings that NMDA receptors play important roles in cellular models of learning as well as neurotoxicity, abnormal function of this receptor has been considered a potential mechanism in the pathophysiology underlying Alzheimer's disease. Treatment of Alzheimer's disease with an NMDA receptor antagonist began several years ago, with some limited success. More recent mechanistic studies have examined the role of NMDA receptors in the synaptic effects of beta amyloid (Aβ).
自最初发现 NMDA 受体在学习和神经毒性的细胞模型中发挥重要作用以来，该受体的异常功能已被认为是阿尔茨海默病病理生理学的潜在机制。几年前，开始使用 NMDA 受体拮抗剂治疗阿尔茨海默病，取得了一定的成效。最近的机制研究检查了 NMDA 受体在β淀粉样蛋白（Aβ）的突触效应中的作用。
