Department of Pharmaceutical Technology, Friedrich Schiller University of Jena, Otto-Schott-Strasse 41, D-07745 Jena, Germany.
J Colloid Interface Sci. 2012 Jan 1;365(1):33-40. doi: 10.1016/j.jcis.2011.09.003. Epub 2011 Sep 10.
This article describes the preparation and the physico-chemical characterization of a new host-guest system consisting of zeolite beta nanoparticles as host and mitoxantrone as guest. The resulting host-guest system mitoxantrone@beta is characterized in terms of morphology (transmission electron microscopy, dynamic light scattering), structure (powder wide-angle X-ray diffraction, nitrogen sorption), surface charge (ξ-potential measurements), and optical properties (UV-visible absorption, steady-state fluorescence). Mitoxantrone@beta particles are monodisperse in size with a mean diameter centered around 100 nm. Mitoxantrone guest molecules are adsorbed at the micropore entrances of zeolite host. Resulting nanoparticles retrieve the interesting optical properties of guest molecules with a fluorescence emission band in the near-infrared region. Mitoxantrone loading is comparatively evaluated by three different means (elemental analysis, direct and indirect UV-visible absorption studies) showing a loading level of 6.8 μmol/g. Mitoxantrone@beta nanoparticles also show a noticeable cytotoxic effect when applied to cancer cells.
本文描述了一种由沸石β纳米粒子作为主体和米托蒽醌作为客体组成的新型主客体体系的制备和物理化学特性。所得的主客体体系米托蒽醌@β在形态（透射电子显微镜，动态光散射）、结构（粉末广角 X 射线衍射，氮气吸附）、表面电荷（ξ-电位测量）和光学性质（紫外-可见吸收，稳态荧光）方面进行了表征。米托蒽醌@β粒子的尺寸呈单分散性，平均直径集中在 100nm 左右。米托蒽醌客体分子吸附在沸石主体的微孔入口处。所得的纳米粒子恢复了客体分子的有趣光学性质，在近红外区域有荧光发射带。通过三种不同的方法（元素分析、直接和间接紫外-可见吸收研究）对米托蒽醌的负载进行了比较评估，结果表明负载水平为 6.8μmol/g。当应用于癌细胞时，米托蒽醌@β纳米粒子也表现出明显的细胞毒性作用。
