Souza Iane M S, García-Villén Fátima, Viseras César, Perger Sibele B C
Laboratório de Peneiras Moleculares, Universidade Federal do Rio Grande do Norte, Natal 59078-970, Brazil.
NanoBioCel Group, Faculty of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain.
Pharmaceutics. 2023 Apr 28;15(5):1352. doi: 10.3390/pharmaceutics15051352.
Development of new medicinal products for particular therapeutic treatment or for better manipulations with better quality and less side effects are possible as a result of advanced inorganic and organic materials application, among which zeolites, due to their properties and versatility, have been gaining attention. This paper is an overview of the development in the use of zeolite materials and their composites and modifications as medicinal products for several purposes such as active agents, carriers, for topical treatments, oral formulations, anticancer, the composition of theragnostic systems, vaccines, parenteral dosage forms, tissue engineering, etc. The objective of this review is to explore the main properties of zeolites and associate them with their drug interaction, mainly addressing the advances and studies related to the use of zeolites for different types of treatments due to their zeolite characteristics such as molecule storage capacity, physical and chemical stability, cation exchange capacity, and possibility of functionalization. The use of computational tools to predict the drug-zeolite interaction is also explored. As conclusion was possible to realize the possibilities and versatility of zeolite applications as being able to act in several aspects of medicinal products.
由于先进的无机和有机材料的应用,开发用于特定治疗或用于质量更好、副作用更少的更好操作的新药品成为可能,其中沸石因其特性和多功能性而受到关注。本文概述了沸石材料及其复合材料和改性物作为药品用于多种目的的发展情况,这些目的包括活性剂、载体、局部治疗、口服制剂、抗癌、诊疗系统的组成、疫苗、肠胃外剂型、组织工程等。本综述的目的是探索沸石的主要特性,并将它们与药物相互作用联系起来,主要论述由于沸石的特性,如分子储存能力、物理和化学稳定性、阳离子交换能力以及功能化可能性,在不同类型治疗中使用沸石的进展和研究。还探讨了使用计算工具预测药物与沸石相互作用的情况。作为结论,可以认识到沸石应用的可能性和多功能性,因为它能够在药品的多个方面发挥作用。