Curr Probl Cardiol. 2011 Nov;36(11):409-53. doi: 10.1016/j.cpcardiol.2011.06.001.
Hypertrophic cardiomyopathy is a fascinating disease of marked heterogeneity. Hypertrophic cardiomyopathy was originally characterized by massive myocardial hypertrophy in the absence of known etiology, a dynamic left ventricular outflow obstruction, and increased risk of sudden death. It is now well accepted that multiple mutations in genes encoding for the cardiac sarcomere are responsible for the disease. Complex morphologic and pathophysiologic differences, disparate natural history studies, and novel treatment strategies underscore the challenge to the practicing cardiologist when faced with the management of the hypertrophic cardiomyopathy patient.
肥厚型心肌病是一种具有显著异质性的迷人疾病。肥厚型心肌病最初的特征是在没有已知病因的情况下心肌大量肥大，左心室流出道动态梗阻，以及猝死风险增加。现在人们普遍认为，编码心肌肌节的多个基因突变是导致这种疾病的原因。复杂的形态和病理生理差异、不同的自然病史研究以及新的治疗策略，都凸显了在面对肥厚型心肌病患者的管理时，对临床心脏病医生的挑战。
