DRiPs 固缩：对内源性 MHC I 抗原加工的理解进展。
DRiPs solidify: progress in understanding endogenous MHC class I antigen processing.
机构信息
Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA.
出版信息
Trends Immunol. 2011 Nov;32(11):548-58. doi: 10.1016/j.it.2011.08.001. Epub 2011 Sep 29.
Abstract
Defective ribosomal products (DRiPs) are a subset of rapidly degraded polypeptides that provide peptide ligands for major histocompatibility complex (MHC) class I molecules. Here, recent progress in understanding DRiP biogenesis is reviewed. These findings place DRiPs at the center of the MHC class I antigen processing pathway, linking immunosurveillance of viruses and tumors to mechanisms of specialized translation and cellular compartmentalization. DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity.
摘要
缺陷核糖体产物 (DRiPs) 是快速降解多肽的一个子集，它们为主要组织相容性复合体 (MHC) Ⅰ类分子提供肽配体。本文综述了近年来对 DRiP 生物发生的认识进展。这些发现使 DRiPs 处于 MHC Ⅰ类抗原加工途径的中心，将病毒和肿瘤的免疫监视与专门的翻译和细胞区室化机制联系起来。DRiPs 使免疫系统能够以极高的灵敏度快速检测细胞基因表达的变化。
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